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Lack of funding
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The purpose of this study is to examine and compare the effects of autogenous dental pulp tissue on bone formation in the extraction sockets as compared to commonly used particulate bone graft. The effects on bone formation will be examined using a wide variety of assays.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Particulate bone graft plus autogenous dental pulp tissue | Experimental | Dental pulp will be isolated from teeth extracted for non-periodontal reasons chairside. The isolated dental pulp will be mixed with hydrated particulate bone graft, and the mixture will be placed in the debrided extraction socket. The socket will be covered by a resorbable collagen membrane and sutured. |
|
| Particulate bone graft | Active Comparator | Hydrated particulate bone graft will be placed in the debrided extraction socket. The socket will be covered by a resorbable collagen membrane and sutured. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Particulate bone graft | Other | Creos allo.gain allogenic bone particulate mineralized cortical bone will be hydrated and placed in the extraction socket. |
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| Measure | Description | Time Frame |
|---|---|---|
| Bone fill as assessed by radiograph | immediately after placement of bone graft | |
| Bone fill as assessed by radiograph | 2 months after placement of bone graft | |
| Bone fill as assessed by radiograph | 4 months after placement of bone graft |
| Measure | Description | Time Frame |
|---|---|---|
| Extent of mineralization as assessed by von Kossa staining | 4 months after placement of bone graft | |
| Extent of mineralization as assessed by Xylenol Orange staining | 4 months after placement of bone graft |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Karo Parsegian, DMD, MDSc, PhD | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D016388 | Tooth Loss |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D014076 | Tooth Diseases |
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| ID | Term |
|---|---|
| D013537 | Sutures |
| ID | Term |
|---|---|
| D053831 | Surgical Fixation Devices |
| D013523 | Surgical Equipment |
| D004864 | Equipment and Supplies |
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| Autogenous dental pulp tissue | Other | Dental pulp will be isolated from teeth extracted for non-periodontal reasons chairside, mixed with hydrated particulate bone graft, and then placed in the extraction socket. |
|
| Resorbable collagen membrane | Other | After placement of particulate bone graft or particulate bone graft plus autogenous dental pulp tissue, socket will be covered by a resorbable collagen membrane and sutured. |
|
| Suture | Other | Resorbable or non-resorbable suture material |
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| Expression of osteoblastic marker Bsp assessed by quantitative PCR (qPCR) | 4 months after placement of bone graft |
| Expression of osteoblastic marker BSP assessed by immunostaining using anti-BSP antibody | 4 months after placement of bone graft |
| Expression of osteoblastic marker Bglap assessed by quantitative PCR (qPCR) | 4 months after placement of bone graft |
| Expression of osteoblastic marker BGLAP assessed by immunostaining using anti-BGLAP antibody | 4 months after placement of bone graft |
| Expression of osteoblastic marker Dmp1 assessed by quantitative PCR (qPCR) | 4 months after placement of bone graft |
| Expression of osteoblastic marker DMP1 assessed by immunostaining using anti-DMP1 antibody | 4 months after placement of bone graft |
| Expression of osteoblastic marker Col1a1 assessed by quantitative PCR (qPCR) | 4 months after placement of bone graft |
| Expression of osteoblastic marker Sost assessed by quantitative PCR (qPCR) | 4 months after placement of bone graft |