The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.

Inclusion Criteria:

• Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant.
• Adjacent and opposing natural teeth present and healthy.
• At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.

Exclusion Criteria:

• Active local infection.
• Uncontrolled diabetes mellitus.
• Long term (>10 years) use of oral bisphosphonates.
• Use of intravenous bisphosphonates.
• Recent use (<3 months) of antibiotics, antiinflammatories or analgesics drugs.
• Pregnancy.
• Smokers of more than 10 cigarettes per day.
• Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.