Immediately following tooth removal, a healing process begins that affects the eventual alveolar bone volume and architecture of the alveolar ridge. Satisfactory and timely healing are essential to obtain ideal functional reconstruction. Traumatic removal of a tooth, or a poor healing response, may lead to excessive bone loss delaying tooth replacement, requiring expensive and time-consuming reconstructive surgeries, or even the inability to be corrected. The Plasma Rich in Growth Factors (PRGF-Endoret) has shown its therapeutic potential effect to minimize the consequences of this aggression, promoting the regeneration of both hard and soft involved tissues.

Inclusion Criteria:

• subjects of both genders and ≥ 18 years old
• Indication of a simple one molar extraction in the mandible.
• Possibility of observation during the follow-up period.

Exclusion Criteria:

• Unerupted third molars or with horizontal inclination.
• Severe swelling prior to surgery in the areas designated for extraction.
• Suffering an alteration or a serious hematologic disease.
• Be currently undergoing or have received radiotherapy, chemotherapy or immunosuppressive therapy, corticosteroids and/or anticoagulants 30 days prior to inclusion
• In regular treatment with NSAIDs or other anti-inflammatory drugs.
• History of chronic hepatitis or cirrhosis.
• Diabetes mellitus with poor metabolic control (glycosylated hemoglobin >9%)
• Patients undergoing dialysis.
• Presence of malignant tumors, hemangiomas or angiomas in the extraction area.
• History of ischemic heart disease in the last year.
• Pregnancy or planned pregnancy during the study follow-up period.
• Metabolic Bone Disease.
• Patients taking bisphosphonates both orally and intravenously.
• In general, any inability to participate in the study.