A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients

A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients

This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.

This observation study is aimed at investigating the gut microbiota alteration in gastrointestinal lymphoma (GIL) patients by performing metagenomic shotgun sequencing on GIL patients' fecal specimen. Before immuno-chemotherapy, the feces specimen of GIL would be collected and stored for further laboratory examination. This study would NOT alter the subsequential treatment of the patients.

Inclusion Criteria:

• Gastrointestinal lymphoma with a clarified pathological diagnosis
• De novo gastrointestinal lymphoma patients who haven't received chemotherapy
• BMI in normal range

Exclusion Criteria:

• Antibiotics or probiotics application within a month
• Overweight (BMI≥25) or malnourished (BMI<18.5) patients
• Patients who have been accepted gastrointestinal fistulation
• Gastrointestinal patients with inflammatory bowel disease (IBD), colorectal carcinoma (CRC) or any other chronic intestinal disease
• Patients infected by HIV