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This is a pilot study aiming at identifying novel therapeutic molecular targets in patients with gastric cancer with lymph nodes or distant metastasis. All patients who are diagnosed with gastric cancer with metastases in the Prince of Wales Hospital will be screened for eligibility.
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| Measure | Description | Time Frame |
|---|---|---|
| Biobank construction | Recruit patients and collect the required biological samples (i.e. tumor tissues, blood and ascites samples) for biobank construction. | Collect at baseline(pre-treatment) and/or during interval surgery if clinically indicated and/or after completing all systemic and surgical treatment if patient required an endoscopy or laparoscopy due to clinical need only. |
| Detection of noval therapeutic targets for treating gastric cancer cancer with metastases. | Biological samples (i.e. tissue, blood and ascites samples) collected from enrolled patients will be used in genome and transcriptome analysis using next generation sequencing, DNA mutation detection using digital PCR and mass spectrometry-based proteomic. | Collect at baseline(pre-treatment) and/or during interval surgery if clinically indicated and/or after completing all systemic and surgical treatment if patient required an endoscopy or laparoscopy due to clinical need only. |
| Organoid culture for drug sensitivity assay | Gastric tumor tissues are collected from enrolled patients to establish patient-derived organoids and subject to drug sensitivity assay. The choice of drugs will depend on the molecular analysis results and will be advised by oncologists. | Collect at baseline(pre-treatment) and/or during interval surgery if clinically indicated and/or after completing all systemic and surgical treatment if patient required an endoscopy or laparoscopy due to clinical need only. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Outcome - Overall survival | Patients' overall survival will also be recorded. | through study completion, an average of 5 year |
| Clinical Outcome - Progression-free survival | Patients' progression-free survival will also be recorded. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients admitted into PWH
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shannon Melissa Chan, PhD | Contact | 35052627 | shannonchan@surgery.cuhk.edu.hk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Chinese University of Hong Kong | Recruiting | Hong Kong | 0000 | Hong Kong |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| D009362 | Neoplasm Metastasis |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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collect required tissue, blood, and ascites samples for further molecular investigations.
| through study completion, an average of 5 year |
| Clinical Outcome - Karnofsky Score | Karnofsky Score for measuring quality of life will be recorded | At baseline measurement |
| Clinical Outcome - Time point of metastasis | Patients' time point of metastasis, whether it is synchronous or metachronous will be recorded | Recruitment till death or 5 year |
| Clinical Outcome - Number of previous chemotherapy/ target therapy/ immunotherapy | Number of previous chemotherapy/ target therapy/ immunotherapy received by the patients will be recorded | Measured and asked at baseline |
| Clinical Outcome - Presence of ascites | Presence of ascites on recruited patients will be recorded | Recruitment till death or 5 year |
| Clinical Outcome - Cancer Restaging | Stage of cancer will be recorded and determined with CT/PETCT scan | Post-treatment till death or 5 year |
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D009385 | Neoplastic Processes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |