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Cordyceps and Rhodiola are two common herbal supplements marketed and consumed as adaptogens to athletes with regard to enhanced performance. The effects of these supplements has been well studied in animals but whether or not the same effects translate to humans is still unclear. Thus, the primary purpose of this study is to determine whether combined supplementation of Rhodiola and Cordyceps, compared to Rhodiola alone and placebo, will demonstrate a greater improvement in oxygen consumption (ie. VO2 max).
Herbal supplements are consumed worldwide with surveys approximating five billion dollars spent annually by consumers in the United States alone. Herbal supplements, such as Rhodiola and Cordyceps, both of which are considered to be adaptogens, remain popular among athletes. These adaptogens act as antioxidants, which have been speculated to confer endurance performance benefits by delaying muscle fatigue via the attenuation of muscle damage accumulation and its related by-products during prolonged or exhaustive exercise. Nevertheless, previous research investigating the individual effects of Rhodiola and Cordyceps on aerobic training performance remain equivocal. Moreover, literature elucidating the potential additive effects of Rhodiola and Cordyceps in human subjects are scarce. Therefore, the purpose of the present study is to determine the acute, additive influence of oral Rhodiola and Cordyceps supplementation on VO2 max, with secondary variables of interest being plasma glucose and lactate concentration, and measures of gastrointestinal distress.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo of calcium | Placebo Comparator | Participants will consume 250 mg of calcium |
|
| Rhodiola | Experimental | Participants will consume 250 mg of Rhodiola |
|
| Rhodiola and Cordyceps | Experimental | Participants will consume a combination of 250 mg of Rhodiola and 225 mg of Cordyceps |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo of calcium | Dietary Supplement | Ingestion of 250 mg of calcium |
| |
| Measure | Description | Time Frame |
|---|---|---|
| VO2 max | Maximum oxygen consumption using the Bruce Protocol | 90 minutes after baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Gastrointestinal symptoms questionnaire | Section 1 contains 6 questions assessing upper abdominal problems (reflux, heartburn, bloating, cramps, vomiting, and nausea). Section 2 contains 7 questions assessing lower abdominal problems (intestinal cramps, flatulence, urge to defecate, left abdominal pain, right abdominal pain, loose stool, and diarrhea). Section 3 contains 4 questions assessing systematic problems (dizziness, headache, muscle cramp, and urge to urinate). Each of the 17 questions is answered using a 10-point scale ranging from 0 (no problem at all) to 10 (the worst it has ever been). Each of the 3 sections will be scored separately. Section 1 will be scored on a scale of 0-60. Section 2 will be scored on a scale of 0-70. Section 3 will be scored on a scale of 0-40. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Todd Hagobian, PhD | California Polytechnic State University-San Luis Obispo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| California Polytechnic State University | San Luis Obispo | California | 93407 | United States |
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Blocked-randomized, crossover design
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| Rhodiola |
| Dietary Supplement |
Ingestion of 250 mg of Rhodiola |
|
| Rhodiola and Cordyceps | Dietary Supplement | Ingestion of 250 mg of Rhodiola and 225 mg of Cordyceps |
|
| Baseline, 90 minutes, 110 minutes |
| Blood glucose | Plasma glucose assessed by finger stick | Baseline, 90 minutes, 110 minutes |
| Blood lactate | Plasma lactate assessed by finger stick | Baseline, 90 minutes, 110 minutes |