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The development of acute kidney injury (AKI) during septic shock is frequent and is associated with a high mortality rate. The reason of this increased mortality despite the use of renal replacement therapy is still unknown. The deleterious effects of uremic toxins (solutes accumulating with the loss of kidney function) has risen for the last decade in chronic kidney disease patients. Among those solutes, indoxyl sulfate (IS) is associated with the development of cardiovascular complications and impairment of immune response. The role of uremic toxins and particularly IS in the prognostic of septic kidney injury is unknown. The investigators propose to analyze the relation between the serum concentration of IS and the mortality of patients hospitalized for a septic shock who developed an AKI.
During chronic kidney disease the uremic toxins have been widely described as potential harmful solutes targeting the cardiovascular system, immunologic system, endothelium and bone metabolism. However, nothing is known about the potential accumulation and pejorative effects of those uremic toxins during AKI (Acute Kidney Injury). The objective of this study is to explore the role of the uremic toxins and specially IS (Indoxyl Sulfate) in the mortality of patients hospitalized for a septic shock and AKI. This study will also describe for the first time the kinetic of the blood concentration of different uremic toxins and their relation with the mortality and the kidney function.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Determination of the blood concentration of indoxyl sulfate (IS) | Diagnostic Test | IS concentration will be determined in blood of patients with septic shock and acute kidney injury. IS blood concentration will be done every day during 7 first days after patient will be admitted in intensive care unit. Relation between IS peak serum concentration and mortality at day 28 will be determined. |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality rate | Mortality of patients hospitalized for a septic shock who developed an acute kidney injury | at day 28 after patient was admitted in intensive care unit |
| Mortality rate | Mortality of patients hospitalized for a septic shock who developed an acute kidney injury | at day 90 after patient was admitted in intensive care unit |
| Measure | Description | Time Frame |
|---|---|---|
| Blood concentration of indoxyl sulfate | Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 1 after patient was admitted in intensive care unit |
| Blood concentration of indoxyl sulfate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| michel slama, Pr | CHU Amiens | Principal Investigator |
| Clement Brautt, MD | CHU Amiens | Principal Investigator |
| Yoan Zerbib, MD | CHU Amiens | Principal Investigator |
| Youssef Bennis, Dr | CHU Amiens | Principal Investigator |
| Sandra Bodeau, Dr | CHU Amiens | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Amiens | 80000 | France |
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Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury |
| at day 2 after patient was admitted in intensive care unit |
| Blood concentration of indoxyl sulfate | Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 3 after patient was admitted in intensive care unit |
| Blood concentration of indoxyl sulfate | Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 4 after patient was admitted in intensive care unit |
| Blood concentration of indoxyl sulfate | Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 5 after patient was admitted in intensive care unit |
| Blood concentration of indoxyl sulfate | Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 6 after patient was admitted in intensive care unit |
| Blood concentration of indoxyl sulfate | Blood concentration of indoxyl sulfate will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 7 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 1 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 2 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 3 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 4 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 5 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 6 after patient was admitted in intensive care unit |
| Blood concentration of para cresyl sulfate (PRS) | Blood concentration of para cresyl sulfate (PRS) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 7 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 1 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 2 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 3 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 4 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 5 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 6 after patient was admitted in intensive care unit |
| Blood concentration of FGF 23 (Fibroblast Growth Factor 23) | Blood concentration of FGF 23 (Fibroblast Growth Factor 23) will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 7 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 1 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 2 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 3 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 4 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 5 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 6 after patient was admitted in intensive care unit |
| Blood concentration of Klotho | Blood concentration of Klotho will be measured in patients hospitalized for a septic shock who developed an acute kidney injury | at day 7 after patient was admitted in intensive care unit |
| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D012772 | Shock, Septic |
| D014115 | Toxemia |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
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