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Randomized, double-blind, before-after controlled trial to assess changes in regional brain activation in response to cigarette-related cues from before to after treatment with bupropion (vs placebo).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bupropion | Experimental | Participants assigned to 150mg of bupropion daily for the first 3 days, followed by titration up to 2 pills daily, separated by 8 hours, for the remaining 8 weeks of treatment. |
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| Placebo | Placebo Comparator | Participants assigned to pill placebo daily for the first 3 days, followed by titration up to 2 pills daily, separated by 8 hours, for the remaining 8 weeks of treatment. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupropion | Drug | Bupropion 150 mg sustained release |
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| Measure | Description | Time Frame |
|---|---|---|
| Craving ratings | Participants were instructed to respond from 1 (definitely not) to 5 (definitely) on the question, "I crave a cigarette right now", after viewing video cues. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Exhaled carbon monoxide (CO) | Participants were asked to hold their breath for as long as possible, ideally 15 seconds, then to breathe out slowly into the mouthpiece of a CO monitor, aiming to empty the lungs completely. | 8 weeks |
| Cigarettes per day |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D012907 | Smoking |
| D000073869 | Tobacco Smoking |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D064424 | Tobacco Use |
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| ID | Term |
|---|---|
| D016642 | Bupropion |
| ID | Term |
|---|---|
| D011427 | Propiophenones |
| D007659 | Ketones |
| D009930 | Organic Chemicals |
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Randomized, double-blind, before-after controlled trial
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Matching placebo pills
| Placebo | Other |
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Self-reported number of cigarettes smoked daily during the past 7 days [??]
| 8 weeks |
| Fagerström Test for Nicotine Dependence (FTND) | The FTND contains six items that evaluate the quantity of cigarette consumption, the compulsion to use, and dependence. The yes/no items are scored from 0 to 1 and multiple-choice items are scored from 0 to 3. The items are summed to yield a total score of 0-10. The higher the total Fagerström score, the more intense is the patient's physical dependence on nicotine. | 8 weeks |