Bupropion and Cigarette-Related Cues in Smokers

Effect of Bupropion Treatment on Brain Activation Induced by Cigarette-Related Cues in Smokers

Randomized, double-blind, before-after controlled trial to assess changes in regional brain activation in response to cigarette-related cues from before to after treatment with bupropion (vs placebo).

Inclusion Criteria:

• Treatment-seeking cigarette smoker
• Meet DSM-IV criteria for nicotine dependence
• Negative result on urine test for drug use during screening

Exclusion Criteria:

• History of any Axis I psychiatric diagnosis other than nicotine dependence
• Medical conditions that might affect brain function
• Current use of medications that could alter brain function
• Pregnancy
• Current illicit drug use other than occasional use of marijuana