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High follicular fluid amyloid A level is associated with reduced pregnancy rate.
The aim of this study was to find an association between serum level of amyloid A and unexplained infertility.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study | Women with unexplained infertility |
| |
| Control | Fertile women who had normal physical and pelvic examination, regular menstrual cycles, don't use hormonal contraceptive, had one child at least. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Serum amyloid A level | Other | For determination of SAA level, a 5-ml sample of venous blood will be taken from each participant under aseptic conditions, and centrifuged at 2500 g for 15 minutes at 4°C c. separated into serum aliquots,and stored frozen at -80°C until analysis of SAA ,which will be done by a double-antibody sandwich Enzyme Linked Immunosorbent Assay (ELISA) kits supplied by cusabio,USA according to manufacturers instruction .Each sample was tested in duplicate and the average will be taken. A cut off level of 30 mg/L SAA level will be chosen to reflect a real increase in its level |
| Measure | Description | Time Frame |
|---|---|---|
| Difference between SAA level between cases and control. | 1 day (once) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between SAA level with other parameters in the hormonal profile (e.g., FSH, LH, E2). | 1 day (once) |
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Inclusion Criteria:
women with unexplained infertility (unprotected, regular intercourse for at least 2 years).
Nulligravida ,Regular mensturation.
Age less than 40 years .
Normal parameters (in the study group):
Exclusion Criteria:
Age above 40
Smoking females
Obesity (BMI>30)
Women with any systemic or medical diseases leads to elevation of SAA as:
Using hormonal contraception (for control group)
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Infertile women attending Ain Shams University infertility outpatient clinic seeking fertility and fulfilling the criteria.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University Hospital | Cairo | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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serum sample
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