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PI left the institution
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The study will examine role of transvenous pacing on coronary microcirculation.
To study the role of transvenous pacing on the coronary microcirculation. This will be accomplished by gathering data from invasive Fractional Flow Reserve (FFR) and Coronary Flow Reserve (CFR) with and without ventricular pacing.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Right ventricular Pacemaker | Other | Patients with right ventricular pacing and evidence of coronary ischemia who have evidence of coronary ischemia who are to undergo coronary angiogram.When an intermediate stenosis (40-80%) has been identified angiographically, this lesion will undergo further hemodynamic assessment, All data including resting flow, FFR, CFR, vital signs, arrhythmias and patient symptoms will be recorded twice: once when the pacemaker is programmed to pace, and once when the PPM is reprogrammed such that the pacemaker is no longer pacing. |
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| Biventricular Pacemaker | Other | Patients with Biventricular pacing and evidence of coronary ischemia who have evidence of coronary ischemia who are to undergo coronary angiogram.When an intermediate stenosis (40-80%) has been identified angiographically, this lesion will undergo further hemodynamic assessment, All data including resting flow, FFR, CFR, vital signs, arrhythmias and patient symptoms will be recorded twice: once when the pacemaker is programmed to pace, and once when the PPM is reprogrammed such that the pacemaker is no longer pacing. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coronary flow and pressure measurement in patients with ventricular pacing | Diagnostic Test | Coronary flow and pressure measurement in patients with ventricular pacing |
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| Measure | Description | Time Frame |
|---|---|---|
| Patients that exhibit coronary microvascular resistance and dysfunction as reflected by FFR | Microvascular dysfunction with pacing | Up to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Patients that exhibit coronary microvascular resistance and dysfunction as reflected by CFR | Microvascular dysfunction with pacing | Up to 12 months |
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Inclusion Criteria:
All patients 19 years of age or older with clinical evidence of coronary ischemia undergoing coronary angiogram, and who have a pacemaker.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nashwa Abdulsalam, MD | University of Nebraska | Principal Investigator |
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| ID | Term |
|---|---|
| D017566 | Microvascular Angina |
| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| D014652 |
| Vascular Diseases |