Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart Failure

Effects of Left Ventricular Pacing Optimilization on Cardiac Perfusion, Contractile Force, and Clinical Performance in Patients With Ventricular Dysfunction and Heart Failure

To compare a surgical approach of LV lead placement for BIV pacing with the conventional transvenous approach by assessment of differences on the effects on cardiac perfusion and relate this to the clinical cardiac function.

Inclusion Criteria:

• Heart failure NYHA III or IV
• QRS duration >120msec or, when paced > 200msec on 12-lead ECG
• LBBB on ecg
• LV ejection fraction 35% or less
• LV dyssynchony on echocardiography

Exclusion Criteria:

• Severe (drug refractory) heart failure with short (<6 months) life expectancy.
• Permanent or persistent atrial fibrillation
• Other indications for cardiac surgery within 6 months
• Life expectancy less than one year due to other conditions
• Major contra-indication for general anaesthesia
• Participation in another study
• Pregnancy or the desire to become pregnant during the follow up of the study.