The purpose of this research study is to develop a psychological treatment for patients with cancer, focused on the psychological symptoms they experience during opioid therapy.

This research study is a treatment development study, which is the first time investigators are developing this psychological intervention in patients with cancer, on opioid therapy. This study is being conducted to develop a psychological intervention designed specifically for individuals with cancer. The purpose of this study is to determine how practical this intervention is, to determine patient satisfaction, and test the study procedures.

Inclusion Criteria:

• must be at least 18 years of age
• speak and comprehend English sufficiently to be able to complete the study procedures and participate in psychotherapy in English
• have been diagnosed with cancer
• have an estimated survival time ≥6 months (as approximated by palliative care clinic staff)
• score ≥4 on the Opioid Risk Tool (Webster & Webster, 2005) with psychosocial distress as one of the positive items.

Exclusion Criteria:

• untreated bipolar disorder
• untreated psychotic disorders
• untreated borderline personality disorder
• have an estimated survival time ≤6 months (as approximated by clinic staff).

All potentially eligible patients will be identified through the DFCI ambulatory palliative care clinics.

The Dana-Farber / Harvard Cancer Center encourages and supports the responsible and ethical sharing of data from clinical trials. De-identified participant data from the final research dataset used in the published manuscript may only be shared under the terms of a Data Use Agreement. Requests may be directed to: [contact information for Sponsor Investigator or designee]. The protocol and statistical analysis plan will be made available on Clinicaltrials.gov only as required by federal regulation or as a condition of awards and agreements supporting the research

Data can be shared no earlier than 1 year following the date of publication

BCH - Contact the Technology & Innovation Development Office at www.childrensinnovations.org or email TIDO@childrens.harvard.edu BIDMC - Contact the Beth Israel Deaconess Medical Center Technology Ventures Office at tvo@bidmc.harvard.edu BWH - Contact the Partners Innovations team at http://www.partners.org/innovation DFCI - Contact the Belfer Office for Dana-Farber Innovations (BODFI) at innovation@dfci.harvard.edu MGH - Contact the Partners Innovations team at http://www.partners.org/innovation