This clinical trial studies whether Acceptance and Commitment Therapy for patients with hepatobiliary cancers (ACT-HBC) can be used to help improve cancer distress. Patients with hepatobiliary cancer (HBC) often experience high levels of distress and reductions in quality of life. ACT-HBC is a behavioral intervention tailored to patients with HBC. It helps patients cope with difficult thoughts and emotions while staying connected to what matters most in life, which may be an effective way to improve cancer distress.

Inclusion Criteria:

• HBC diagnosis
• Age >= 18 years
• Able to provide written informed consent
• Verbally endorse cancer distress
• Access to the internet
• Read and write in English
• Reside in the states of Iowa, Minnesota, or Wisconsin

Exclusion Criteria:

• Other psychological therapy that started =< 2 months prior to prospective enrollment
• Inability to actively participate in and learn from group therapy (e.g., active/uncontrolled psychotic symptoms, neurological condition, personality pathology) as determined by clinical judgement in Behavioral Medicine Program (BMP) consultation. Individual therapy or alternative group therapy will be offered to patients ineligible per this criterion
• HBC remission