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Several drugs and chemotherapies seem to induce uveitis. This study investigates reports of uveitis, including the International classification of disease ICD-10 for treatments in the World Health Organization (WHO) global Individual Case Safety Report (ICSR) database (VigiBase).
Several drugs and chemotherapies seem to have an impact on the eyes and are responsible of uveitis. Those are poorly described, due to the modification of the pharmacopeia, and the recent recognition of several of these adverse events. This study investigates the main characteristics of patients affected by uveitis side effect imputed to drugs. A causality assessment according to the WHO-UMC (World Health Organization - Uppsala Monitoring Center) is systematically applied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Uveitis induced by drugs and chemotherapies | Case reported in the World Health Organization (WHO) of uveitis of patient treated by a drug, with a chronology compatible with the drug toxicity |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Drugs inducing uveitis | Drug | Drugs susceptible to induce uveitis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Eye toxicities of drugs Identification and report of cases of uevitis associated with drugs | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |
| Measure | Description | Time Frame |
|---|---|---|
| Causality assessment of reported uveitis according to the WHO system | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |
| All relevants statisticals associations between type of uveitis and the category of drug |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with a drug that could be reported in the WHO's pharmacovigilance database
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, CIC-1421, Pharmacovigilance Unit, INSERM | Paris | 75013 | France |
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| ID | Term |
|---|---|
| D014605 | Uveitis |
| D005128 | Eye Diseases |
| ID | Term |
|---|---|
| D014603 | Uveal Diseases |
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Case reported in the World Health Organization (WHO) database of individual safety case reports |
| to 01/04/2019 |
| All relevants statisticals associations between other concomittants immune related adverse events and uveitis induced by drugs | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |
| Duration of treatment when uveitis happen (role of cumulative dose) | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |
| All relevants statisticals associations between drug-drug interactions and adverse events | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |
| All relevants statisticals associations between pathologies (cancer) for which the incriminated drugs have been prescribed, and occurence of uveitis | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |
| All relevants statisticals associations between characteristics of the population and occurence of uveitis adverse event | Case reported in the World Health Organization (WHO) database of individual safety case reports | to 01/04/2019 |