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| ID | Type | Description | Link |
|---|---|---|---|
| 2018-A03239 | Other Identifier | ID-RCB |
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| Name | Class |
|---|---|
| URC-CIC Paris Descartes Necker Cochin | OTHER |
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Auditory Processing Disorder (APD) affects 0.5-7% of the pediatric population. This disorder is responsible for a child's low hearing ability. The diagnosis of APD is difficult because of polymorphic symptoms possibly entangled with other difficulties (learning, communication, attention ...). There is currently no gold standard in the literature for diagnosing APD. Investigators opened multidisciplinary consultation for the children suspected of APD. The purpose of this study is to analyze the results of the multidisciplinary assessment performed on these children (audiometry, cortical auditory brainstem response (ABR), behavioral assessment, psychometric evaluation, genetic analysis) to the results of functional MRI (fMRI) at rest and in activation. The goal is to find radiological MRI-fMRI markers in these patients that improve the diagnosis of APD.
Investigators will compare the f-MRI results between three groups of children in order to find specific radiological markers of APD :
The study will include a multidisciplinary consultation with:
The purpose of the study is looking for objective biomarkers of APD:
With this multidisciplinary evaluation, the investigators wish to improve the diagnosis of APD in suspected children by associating clinical, radiological, electro-physiological and genetic criteria.
Better understanding and more accurate diagnosis of APD's will improve the care management of these children.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| confirmed auditory processing disorders | Experimental | functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic |
|
| suspected not confirmed auditory processing disorders | Experimental | functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic |
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| healthy volunteers | Active Comparator | functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic, multidisciplinary consultation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| functional MRI | Diagnostic Test | Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care |
|
| Measure | Description | Time Frame |
|---|---|---|
| BOLD effect | BOLD effect is measured during fMRI and compared between the 3 groups of patients | up to 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| set disyllabic words (Fournier or Boorsma lists) | Speech evaluation : set disyllabic words using the Fournier or Boorsma lists (the French equivalent of the. Peabody PBK test), depending on age | up to 4 weeks |
| RapDys |
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Inclusion Criteria Group 1 & 2: :
Inclusion Criteria Group 3:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Isabelle Rouillon, MD, PhD | Assistance Publique - Hôpitaux de Paris | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Necker Hospital | Paris | 75015 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28635503 | Background | Chermak GD, Bamiou DE, Vivian Iliadou V, Musiek FE. Practical guidelines to minimise language and cognitive confounds in the diagnosis of CAPD: a brief tutorial. Int J Audiol. 2017 Jul;56(7):499-506. doi: 10.1080/14992027.2017.1284351. Epub 2017 Feb 28. | |
| 20660546 | Background | Moore DR, Ferguson MA, Edmondson-Jones AM, Ratib S, Riley A. Nature of auditory processing disorder in children. Pediatrics. 2010 Aug;126(2):e382-90. doi: 10.1542/peds.2009-2826. Epub 2010 Jul 26. |
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| Automated Cortical Brainstem Auditory Evoked Potential | Diagnostic Test | Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG |
|
| whole exome sequencing | Genetic | A study of all the DNA-encoding exons of the child/parent from a sample taken as part of the usual care |
|
| Standard Cortical Brainstem Auditory Evoked Potential | Diagnostic Test | Standard Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG |
|
| multidisciplinary consultation | Diagnostic Test | multidisciplinary consultation is composed of:
|
|
Speech evaluation
| up to 4 weeks |
| Random Gap Detection Test (RGDT) | Speech evaluation | up to 4 weeks |
| Dichotic listening test | Speech evaluation | up to 4 weeks |
| temporal pattern recognition test | Speech evaluation | up to 4 weeks |
| Test of Everyday Attention for Children (TEA-Ch test) | Psychometric evaluation for children aged 7-12 years | up to 4 weeks |
| Wechsler Intelligence Scale for Children (WISC-V) test | Psychometric evaluation for children aged 13-18 years | up to 4 weeks |
| Chromosomal analysis (group 1 only) | Genetic analysis | up to 12 months |
| Work Environment Scale (WES) sequencing (group 1 only) | Genetic analysis | up to 12 months |
| Measures of P1, N1, P2, N2 waves' Latencies | Cortical Brainstem Auditory Evoked | At inclusion day (visit 1) and at 12 months (group 1 and 2 only) |
| Measures of P1, N1, P2, N2 waves' amplitudes | Cortical Brainstem Auditory Evoked | At inclusion day (visit 1) and at 12 months (group 1 an 2 only) |
| Infusion Rate (MRI-ASL) | Infusion Rate (MRI-ASL) is measured during MRI | up to 4 weeks |
| tractography results (DTI sequence) | tractography results (DTI sequence) is measured during MRI | up to 4 weeks |
| 28590897 | Background | Barker MD, Kuruvilla-Mathew A, Purdy SC. Cortical Auditory-Evoked Potential and Behavioral Evidence for Differences in Auditory Processing between Good and Poor Readers. J Am Acad Audiol. 2017 Jun;28(6):534-545. doi: 10.3766/jaaa.16054. |
| 27587924 | Background | Tomlin D, Rance G. Maturation of the Central Auditory Nervous System in Children with Auditory Processing Disorder. Semin Hear. 2016 Feb;37(1):74-83. doi: 10.1055/s-0035-1570328. |
| 19064904 | Background | Sharma M, Purdy SC, Kelly AS. Comorbidity of auditory processing, language, and reading disorders. J Speech Lang Hear Res. 2009 Jun;52(3):706-22. doi: 10.1044/1092-4388(2008/07-0226). Epub 2008 Dec 8. |
| 27082630 | Background | de Wit E, Visser-Bochane MI, Steenbergen B, van Dijk P, van der Schans CP, Luinge MR. Characteristics of Auditory Processing Disorders: A Systematic Review. J Speech Lang Hear Res. 2016 Apr 1;59(2):384-413. doi: 10.1044/2015_JSLHR-H-15-0118. |
| 14714945 | Background | Demanez L, Dony-Closon B, Lhonneux-Ledoux E, Demanez JP. Central auditory processing assessment: a French-speaking battery. Acta Otorhinolaryngol Belg. 2003;57(4):275-90. |
| 9402896 | Background | Sharma A, Kraus N, McGee TJ, Nicol TG. Developmental changes in P1 and N1 central auditory responses elicited by consonant-vowel syllables. Electroencephalogr Clin Neurophysiol. 1997 Nov;104(6):540-5. doi: 10.1016/s0168-5597(97)00050-6. |
| 12151804 | Background | Sharma A, Dorman MF, Spahr AJ. Rapid development of cortical auditory evoked potentials after early cochlear implantation. Neuroreport. 2002 Jul 19;13(10):1365-8. doi: 10.1097/00001756-200207190-00030. |
| 16295243 | Background | Sharma A, Martin K, Roland P, Bauer P, Sweeney MH, Gilley P, Dorman M. P1 latency as a biomarker for central auditory development in children with hearing impairment. J Am Acad Audiol. 2005 Sep;16(8):564-73. doi: 10.3766/jaaa.16.8.5. |
| 24273704 | Background | Sharma A, Glick H, Campbell J, Biever A. CENTRAL AUDTIORY DEVELOPMENT IN CHILDREN WITH HEARING LOSS: CLINICAL RELEVANCE OF THE P1 CAEP BIOMARKER IN HEARING-IMPAIRED CHILDREN WITH MULTIPLE DISABILITIES. Hearing Balance Commun. 2013 Sep;11(3):10.3109/21695717.2013.812378. doi: 10.3109/21695717.2013.812378. |
| Background | Sharma M, Purdy S C, Kelly A S. The contribution of speech-evoked cortical auditory evoked potentials to the diagnosis and measurement of intervention outcomes in children with auditory processing disorder. Semin Hear. 2014;35(1):51-64 |
| 12199513 | Background | Purdy SC, Kelly AS, Davies MG. Auditory brainstem response, middle latency response, and late cortical evoked potentials in children with learning disabilities. J Am Acad Audiol. 2002 Jul-Aug;13(7):367-82. |
| 20950282 | Background | Anderson S, Chandrasekaran B, Yi HG, Kraus N. Cortical-evoked potentials reflect speech-in-noise perception in children. Eur J Neurosci. 2010 Oct;32(8):1407-13. doi: 10.1111/j.1460-9568.2010.07409.x. |
| 11132782 | Background | Cunningham J, Nicol T, Zecker S, Kraus N. Speech-evoked neurophysiologic responses in children with learning problems: development and behavioral correlates of perception. Ear Hear. 2000 Dec;21(6):554-68. doi: 10.1097/00003446-200012000-00003. |
| 27587921 | Background | Punch S, Van Dun B, King A, Carter L, Pearce W. Clinical Experience of Using Cortical Auditory Evoked Potentials in the Treatment of Infant Hearing Loss in Australia. Semin Hear. 2016 Feb;37(1):36-52. doi: 10.1055/s-0035-1570331. |
| 18453883 | Background | Martin BA, Tremblay KL, Korczak P. Speech evoked potentials: from the laboratory to the clinic. Ear Hear. 2008 Jun;29(3):285-313. doi: 10.1097/AUD.0b013e3181662c0e. |
| 26915160 | Background | Micallef LA. Auditory Processing Disorder (APD): Progress in Diagnostics So Far. A Mini-Review on Imaging Techniques. J Int Adv Otol. 2015 Dec;11(3):257-61. doi: 10.5152/iao.2015.1009. |
| 24179836 | Background | Owen JP, Marco EJ, Desai S, Fourie E, Harris J, Hill SS, Arnett AB, Mukherjee P. Abnormal white matter microstructure in children with sensory processing disorders. Neuroimage Clin. 2013 Jun 23;2:844-53. doi: 10.1016/j.nicl.2013.06.009. eCollection 2013. |
| 19058816 | Background | Kim MJ, Jeon HA, Lee KM, Son YD, Kim YB, Cho ZH. Neuroimaging features in a case of developmental central auditory processing disorder. J Neurol Sci. 2009 Feb 15;277(1-2):176-80. doi: 10.1016/j.jns.2008.10.020. Epub 2008 Dec 6. |
| 10659849 | Background | Belin P, Zatorre RJ, Lafaille P, Ahad P, Pike B. Voice-selective areas in human auditory cortex. Nature. 2000 Jan 20;403(6767):309-12. doi: 10.1038/35002078. |
| 14741658 | Background | Thomsen T, Rimol LM, Ersland L, Hugdahl K. Dichotic listening reveals functional specificity in prefrontal cortex: an fMRI study. Neuroimage. 2004 Jan;21(1):211-8. doi: 10.1016/j.neuroimage.2003.08.039. |
| 25261349 | Background | Pluta A, Wolak T, Czajka N, Lewandowska M, Ciesla K, Rusiniak M, Grudzien D, Skarzynski H. Reduced resting-state brain activity in the default mode network in children with (central) auditory processing disorders. Behav Brain Funct. 2014 Sep 26;10(1):33. doi: 10.1186/1744-9081-10-33. |
| 20363995 | Background | Bartel-Friedrich S, Broecker Y, Knoergen M, Koesling S. Development of fMRI tests for children with central auditory processing disorders. In Vivo. 2010 Mar-Apr;24(2):201-9. |
| ID | Term |
|---|---|
| D001308 | Auditory Perceptual Disorders |
| ID | Term |
|---|---|
| D001304 | Auditory Diseases, Central |
| D012181 | Retrocochlear Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| D000073359 | Exome Sequencing |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D000073336 | Whole Genome Sequencing |
| D017422 | Sequence Analysis, DNA |
| D017421 | Sequence Analysis |
| D005821 | Genetic Techniques |
| D008919 | Investigative Techniques |
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