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Study protocol no longer relevant after progression of the scientific field
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The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Habitual activity and 2 days bed rest | Experimental | Participants will undergo 2 days of habitual activity and 2 days bed rest |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Habitual activity | Behavioral | Two days of habitual physical activity, under normal free-living conditions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in whole-body insulin sensitivity | Change in whole-body insulin sensitivity via meal tolerance test | During 2 days of habitual physical activity and 2 days of bed rest. Blood glucose and insulin are monitored for 2 hours following ingestion of a standardized meal |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cumulative muscle protein synthesis | Cumulative muscle protein synthesis via deuterium oxide ingestion. The incorporation of deuterated alanine in muscle is expressed relative to body water enrichments, to obtain muscle protein synthesis in %/day | During 2 days of habitual physical activity and 2 days of bed rest |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marlou L Dirks, PhD | University of Exeter | Principal Investigator |
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| ID | Term |
|---|---|
| D001510 | Bed Rest |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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Participants will firstly undergo 2 days of habitual physical activity, followed by 2 days of bed rest
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| Bed rest | Behavioral | Two days of bed rest, to induce whole-body physical inactivity |
|
| Change in continuous glucose |
Change in continuous glucose via continuous glucose monitoring. |
| Continuous glucose, during the 2 days of habitual activity and 2 days of bed rest |
| Change in muscle volume | Change in muscle volume via MRI | Immediately before and immediately after the 2-day bed rest period |