Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis

The Impact of Two Days of Bed Rest Versus Two Days of Habitual Activity on Insulin Sensitivity and Cumulative Muscle Protein Synthesis in Healthy Young Males

The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Inclusion Criteria:

• Male
• Aged 18-40

Exclusion Criteria:

• Smoker
• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
• Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)
• Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
• A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
• Any known disorders in muscle metabolism
• Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)
• Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
• Allergy to lidocaine
• Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)