Bed-rest, Muscle Mass and Insulin Sensitivity

The Impact of Short-term Bed-rest on Skeletal Muscle Mass and Insulin Sensitivity in Healthy, Young Men

In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.

Inclusion Criteria:

• Male
• Aged from 18-35 years
• 18.5 < BMI < 30 kg/m2

Exclusion Criteria:

• Smoking
• Performing regular resistance training (3+ times per week, carrying out progressive training) in the previous 6 months
• Hypertension (according to WHO criteria) and/or cardiovascular disease
• Any back/leg/knee/neck/postural complaints
• Use of any prescribed medication
• Type 2 diabetes mellitus
• Any family history of thrombosis
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis).
• Myocardial infarction within the last 3 years
• Use of anti-coagulants