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In the present study, the effects of 7 days of bed rest on muscle mass, muscle fiber characteristics and insulin sensitivity will be determined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bed rest | Experimental | One week of bed rest. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bed rest | Behavioral |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in quadriceps muscle cross-sectional area | One day before and directly after cessation of bed rest. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in lower back cross-sectional area | One day before and directly after cessation of bed rest. | |
| Change in leg and whole body lean tissue mass | One day before and directly after cessation of bed rest. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luc JC van Loon, PhD | Maastricht UMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Centre | Maastricht | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27358494 | Derived | Dirks ML, Wall BT, van de Valk B, Holloway TM, Holloway GP, Chabowski A, Goossens GH, van Loon LJ. One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation. Diabetes. 2016 Oct;65(10):2862-75. doi: 10.2337/db15-1661. Epub 2016 Jun 29. | |
| 27124248 |
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| ID | Term |
|---|---|
| D020966 | Muscular Disorders, Atrophic |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D001510 | Bed Rest |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Change in muscle fiber size | One day before and directly after cessation of bed rest. |
| Change in muscle strength | Measured by 1-Repetition Maximum testing | One day before and directly after cessation of bed rest. |
| Change in insulin sensitivity | Measured by hyperinsulinemic-euglycemic clamp | One day before and directly after cessation of bed rest. |
| Dirks ML, Backx EM, Wall BT, Verdijk LB, van Loon LJ. May bed rest cause greater muscle loss than limb immobilization? Acta Physiol (Oxf). 2016 Sep;218(1):10-2. doi: 10.1111/apha.12699. Epub 2016 May 20. No abstract available. |