Multi-dose Ibuprofen Prophylaxis for IUD-insertion

Multi-dose Ibuprofen Prophylaxis for IUD-insertion (MIPI): A Triple Blinded

This study compares the effectiveness of decreasing pain at time of and day after intrauterine device (IUD) insertion when patients take three doses of Ibuprofen versus three doses of placebo.

Ibuprofen is commonly used over the counter and prescribed for pain relief such as menstrual cramps. Intrauterine (IUD) insertion can cause pain during and after the insertion. Currently, studies have found that single dose of Ibuprofen take prior to IUD insertion does decrease pain at time of IUD insertion. This study will examine whether 3 doses of Ibuprofen can decrease pain at time of and 1 day after IUD insertion.

Inclusion Criteria:

• Age ≥ 18
• Female
• Able to provide informed consent
• English speaking
• Able to provide telephone and address contact information
• Able and willing to receive HIPAA compliant telephone texts and phone messages
• Stable (the same) address and phone number within the last 6 months.

Exclusion Criteria:

• Contraindications to IUD insertion (active pelvic infection, current pregnancy)
• Contraindications to NSAIDs (allergy, history of asthma, history of aspirin allergy, history of kidney disease, history of stomach ulcer, history of active GI bleeding, history of liver disease)
• Not undergoing any other concurrent office procedures