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PI passed away. Ending grant and closing lab.
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In this study, the investigators will study one of the basic biophysical properties of the auditory nerve, charge integration, behaviorally (detection threshold versus phase duration functions). The investigators will compare charge integration in two subject groups: congenitally deafened and deafened at a later age in life. The investigators will then examine if behaviorally estimated neural excitation patterns differ between short phase duration and long phase duration stimulation. Lastly, The investigators will measure if speech recognition improves with using long phase duration stimulation, relative to using the standard default short phase duration stimulation. The primary endpoint of the study is speech recognition, and the secondary endpoints are the steepness of the detection threshold versus phase duration functions, and the width of psychophysically estimated neural excitation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cochlear implant users with late-onset deafness | Examine charge integration (Detection threshold as a function of phase duration). Examine neural spatial excitation patterns with long and short phase duration. Measure speech recognition using long and short phase duration stimulation patterns. |
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| Cochlear implant users with early-onset deafness | Examine charge integration (Detection threshold as a function of phase duration) and compare that with the late-onset group. Examine neural spatial excitation patterns with long and short phase duration within the non-leaky phase duration range. Measure speech recognition using long and short phase duration stimulation patterns. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phase duration | Behavioral | We will vary the phase duration in the stimulation, and examine detection threshold, spatial spread of neural excitation, and speech recognition as the outcomes. |
| Measure | Description | Time Frame |
|---|---|---|
| Slope of the strength duration function | Subjects will be measured for detection thresholds as a function of phase duration of the pulse train and the slope of the function will be derived. | starting 6 months post award notice and will take up to 4 years to complete |
| Measure | Description | Time Frame |
|---|---|---|
| Psychophysically estimated neural excitation width | Subjects will be measured for psychophysical forward-masked spatial tuning curves using stimuli with long and short phase duration. | starting 6 months post award notice and will take up to 4 years to complete |
| Speech recognition using long phase duration |
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Inclusion Criteria:
Exclusion Criteria:
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Children and adults with cochlear implants (Advanced Bionics and Cochlear Nucleus devices)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Communication Sciences and Disorders, ECU | Greenville | North Carolina | 27834 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23462803 | Background | Hancock KE, Chung Y, Delgutte B. Congenital and prolonged adult-onset deafness cause distinct degradations in neural ITD coding with bilateral cochlear implants. J Assoc Res Otolaryngol. 2013 Jun;14(3):393-411. doi: 10.1007/s10162-013-0380-5. Epub 2013 Mar 5. | |
| 20962228 | Background | Hancock KE, Noel V, Ryugo DK, Delgutte B. Neural coding of interaural time differences with bilateral cochlear implants: effects of congenital deafness. J Neurosci. 2010 Oct 20;30(42):14068-79. doi: 10.1523/JNEUROSCI.3213-10.2010. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 30, 2024 | |
| Reset | Sep 3, 2024 | |
| Release | Feb 24, 2025 | |
| Reset | Mar 4, 2025 | |
| Release | Mar 13, 2025 | |
| Reset | Mar 24, 2025 | |
| Release | Apr 3, 2025 | |
| Reset | Apr 22, 2025 | |
| Release | Jul 15, 2025 | |
| Reset | Aug 1, 2025 | |
| Release | Sep 19, 2025 | |
| Reset | Oct 6, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 30, 2024 | Sep 3, 2024 | |||
| Feb 24, 2025 |
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Subjects' speech recognition performance will be evaluated using CUNY and TIMIT sentences with long and short phase duration stimulation. |
| starting 6 months post award notice and will take up to 4 years to complete |
| 10082295 | Background | Hardie NA, Shepherd RK. Sensorineural hearing loss during development: morphological and physiological response of the cochlea and auditory brainstem. Hear Res. 1999 Feb;128(1-2):147-65. doi: 10.1016/s0378-5955(98)00209-3. |
| 10962187 | Background | Leake PA, Snyder RL, Rebscher SJ, Moore CM, Vollmer M. Plasticity in central representations in the inferior colliculus induced by chronic single- vs. two-channel electrical stimulation by a cochlear implant after neonatal deafness. Hear Res. 2000 Sep;147(1-2):221-41. doi: 10.1016/s0378-5955(00)00133-7. |
| 22423717 | Background | McKay CM. Forward masking as a method of measuring place specificity of neural excitation in cochlear implants: a review of methods and interpretation. J Acoust Soc Am. 2012 Mar;131(3):2209-24. doi: 10.1121/1.3683248. |
| 2744791 | Background | Rattay F. Analysis of models for extracellular fiber stimulation. IEEE Trans Biomed Eng. 1989 Jul;36(7):676-82. doi: 10.1109/10.32099. |
| 17828665 | Background | Sharma A, Gilley PM, Dorman MF, Baldwin R. Deprivation-induced cortical reorganization in children with cochlear implants. Int J Audiol. 2007 Sep;46(9):494-9. doi: 10.1080/14992020701524836. |
| 11273423 | Background | Svirsky MA, Robbins AM, Kirk KI, Pisoni DB, Miyamoto RT. Language development in profoundly deaf children with cochlear implants. Psychol Sci. 2000 Mar;11(2):153-8. doi: 10.1111/1467-9280.00231. |
| 15454759 | Background | Teoh SW, Pisoni DB, Miyamoto RT. Cochlear implantation in adults with prelingual deafness. Part II. Underlying constraints that affect audiological outcomes. Laryngoscope. 2004 Oct;114(10):1714-9. doi: 10.1097/00005537-200410000-00007. |
| 7130465 | Background | Trune DR. Influence of neonatal cochlear removal on the development of mouse cochlear nucleus: I. Number, size, and density of its neurons. J Comp Neurol. 1982 Aug 20;209(4):409-24. doi: 10.1002/cne.902090410. |
| 6480511 | Background | van den Honert C, Stypulkowski PH. Physiological properties of the electrically stimulated auditory nerve. II. Single fiber recordings. Hear Res. 1984 Jun;14(3):225-43. doi: 10.1016/0378-5955(84)90052-2. |
| 19275322 | Background | Kong YY, Deeks JM, Axon PR, Carlyon RP. Limits of temporal pitch in cochlear implants. J Acoust Soc Am. 2009 Mar;125(3):1649-57. doi: 10.1121/1.3068457. |
| Mar 4, 2025 |
| Mar 13, 2025 | Mar 24, 2025 |
| Apr 3, 2025 | Apr 22, 2025 |
| Jul 15, 2025 | Aug 1, 2025 |
| Sep 19, 2025 | Oct 6, 2025 |