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Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information.
Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group.
Primary purpose:
To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group.
Secondary purposes:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| EPILEPSY GROUP | Experimental | Patients with typical BECTS (benign group) or atypical BECTS or ECSWS (severe group) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography (standard of care procedure): 2h wake and whole night Sleep diary |
|
| CONTROL GROUP | Other | Patients hospitalized for non neurologic illness (diabetes, nephropathy, chronic intestinal disease) Medical visit Neuropsychological testing Neuropsychological procedure Video EEG and polysomnography : 2h wake and whole night Sleep diary |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological testing | Behavioral | memory, executive testing, behaviour questionnaire, visual attention, |
|
| Measure | Description | Time Frame |
|---|---|---|
| memory lapse rate at 24 hours in the severe group, the benign group and the control group. ("memory lapse rate": rate of non recalled words number, during the delayed recall phase of the test, related to the maximal number of words recalled | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| memory lapse rate for each group | at 1 hour, 5 hours, 24 hours | |
| Correlation of memory lapse rate with Executive functioning tests scores | at 1 hour, 5 hours, 24 hours | |
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Inclusion Criteria:
Principal:
Specific
Patients from "severe" and "benign" groups:
Control group
-children hospitalized for a non neurologic disease
Exclusion Criteria:
Principal:
Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care
Specific
Patients from "severe" and "benign" groups:
Control group
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anne DE SAINT MARTIN, MD | Contact | + 33 3.88.12.83.98 | anne.desaintmartin@chru-strasbourg.fr | |
| Lucille SCHNEIDER | Contact | lucille.schneider@chru-strasbourg.fr |
| Name | Affiliation | Role |
|---|---|---|
| Anne DE SAINT MARTIN, MD | Hôpitaux Universitaires de Strasbourg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital D'Enfants Pediatrie Medicale Ambulatoire | Recruiting | Nancy | 54511 | France |
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| Neuropsychological procedure | Behavioral | Rey auditory verbal learning test, Delayed recall : 1h, 5h, 24h (after one night sleep) |
|
| Video EEG and polysomnography | Other | Video EEG : 10 electrodes + 3 electrodes for PSG 2h wake EEG Whole night EEG |
|
| Correlation of memory lapse rate with age of onset, epilepsy phase, treatment |
| at 1 hour, 5 hours, 24 hours |
| Correlation of memory lapse rate with EEG severity scale, atypical criteria, EEG focus localization, sleep discharges frequency | at 1 hour, 5 hours, 24 hours |
| Correlation of memory lapse rate with number and organization of sleep cycles | at 1 hour, 5 hours, 24 hours |
| Hopital de Hautepierre-Service de Pediatrie/Neurologie | Recruiting | Strasbourg | 67098 | France |
|
| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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