Early Diagnosis for Ocular Ischemia Syndrome Using Arterial Spin Labeling Magnetic Resonance Imaging Technique

Early Diagnosis for Ocular Ischemia Syndrome Using Arterial Spin Labeling Magnetic Resonance Imaging Technique: a Prospective Multicenter Cohort Study

1. To evaluate ocular blood perfusion status and the possibility of craniocerebral vascular lesions of patients with ocular ischemia syndrome (OIS) using arterial spin labeling (ASL) magnetic resonance imaging technique.
2. To evaluate the specificity, sensitivity and accuracy of arterial spin labeling (ASL) magnetic resonance imaging technique in OIS diagnosis, compared with the traditional routine examination method.

Inclusion Criteria:

• Ocular ischemia syndrome group: Patients diagnosed with ocular ischemia syndrome;
• Age-related macular degeneration group (Control group): Patients diagnosed with age-related macular degeneration;
• Age: 50-80 years;
• Sex: all;
• Patients signed written informed consent.

Exclusion Criteria:

• Fundus fluorescein angiography (FFA) clear images cannot be obtained due to refractive media problems(such as corneal leukoplakia, severe cataract, vitreous hemorrhage, etc.) ;
• Patients with contraindications for FFA;
• Patients was unable to perform magnetic resonance rmaging (MRI) test;
• Patients with history of bleeding and cerebral infarction;
• Patients with a history of surgery within 3 months;
• Patients who had participated in other clinical trials within 3 months;
• Patients who disagree and refuse to participate in the trial.