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| Name | Class |
|---|---|
| National Key Research and Development Project, China | UNKNOWN |
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The goal of this observational study is to explore the ability of intravascular pressure gradients to identify hemodynamic disturbance in patients with intracranial atherosclerotic diseases (ICAS). The main questions that aim to answer are:
Patients will undergo intravascular pressure measurement and arterial spin labeling (ASL) for CBF during pre- and post-operation respectively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ICAS patients planning for endovascular treatment | Patients received pressure-wire-based intravascular pressure measurement and ASL measurement before and after operation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endovascular treatment | Procedure | Patients treated with endovascular treatment, including balloon angioplasty alone and balloon angioplasty plus stenting. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The relevance between intravascular pressure gradients and CBF | Patients will be divided into 2 groups according to whether they have hemodynamic disorders before operation and improve after operation. Fractional flow reserve (FFR) measurement will be analyzed in each group. | Post-operation, an average of 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| The difference of ASL-CBF between pre- and post-operation | The mean cerebral blood flow (CBF) of ipsilateral region of interest (ROI) in two different layers will be recorded as CBF in MCA perfusion area of this side. Relative CBF (rCBF) is defined as the ratio of the affected side CBF to the contralateral CBF. When preoperative rCBF<0.9 and postoperative rCBF≥0.9, the patient will be considered to have hemodynamic disorders and be improved post-operation. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with symptomatic ICAS resorting to endovascular therapy in our center were recruited consecutively.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuanwu Hospital, Capital Medical University | Beijing | Beijing Municipality | China |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| D002537 | Intracranial Arteriosclerosis |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Baseline and Post-operation, an average of 3 days |
| The difference of FFR between pre- and post-operation | FFR measurement will be performed at rest by 0.014-inch pressure guide wires (C12008, Abbot St. Jude Medical, Minneapolis, MN, USA) designed for coronary diseases. The mean endovascular pressure of distal and proximal lesions will be measured and recorded as Pd and Pa, respectively. Pd/Pa and Pa-Pd will be calculated and recorded before and after endovascular treatment. | Baseline and Post-operation, an average of 3 days |
| Any stroke or death in short term. | 30±5 days |
| Procedure-related complications | Any complications, related to manometry and treatment, will be recorded including arterial dissection, arterial perforation, acute vascular occlusion and other adverse events. | 30±5 days |
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D020765 | Intracranial Arterial Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |