The Effect of Lipid Emulsions on Free Fatty Acids and Free Bilirubin in Premature Newborns

The Effect of Lipid Emulsions on Free Fatty Acids and Free Bilirubin in Premature Newborns

The goal of this research study is to compare the levels of free fatty acids and free bilirubin between two intravenous lipid emulsion products in premature newborns.

Inclusion Criteria:

• premature newborns (<32 weeks gestation, stratified <28 weeks versus >28 weeks) <8 days of age
• receiving lipid infusions <1 g/kg/day at enrollment
• anticipated to be treated with 3 g/kg/day for a minimum of 48 hours.

Exclusion Criteria:

• patients with direct hyperbilirubinemia >1.5 mg/dl
• with suspected sepsis meeting Systemic inflammatory response syndrome (SIRS) criteria
• undergoing treatment with a continuous infusion of morphine
• with a continuous infusion of pressors (dopamine, dobutamine, epinephrine, etc.)
• positive blood cultures