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The aim of this study was to verify the prognostic value of functional kidney biomarkers on survival and renal function recovery in cardiac surgery patients with acute kidney injury.
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the second most common type of AKI after septic AKI and is associated with increased mortality and morbidity. Few biomarkers were validated as outcome-specific biomarkers in patients developing AKI after cardiac surgery at initiation of RRT. This study was designed to not only verify the prognostic value of functional kidney biomarkers on survival, but also predict it severity in order to optimize clinical decision making with respect to dialysis initiation and discontinuation.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Renal Replacement Therapy | Other | Indications for RRT were defined as previously reported.
|
| Measure | Description | Time Frame |
|---|---|---|
| 28-day mortality | Death from any cause at 28 days | 28 days |
| Dependence on renal-replacement therapy at 28 days in survivors | Dependence on renal-replacement therapy was defined as surviving dependent on RRT | 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| 60- and 90-day mortality | Death from any cause at 60- and 90-days | Up to 60 or 90 days |
| Length of stay in the ICU | the length of stay in the ICU |
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Inclusion Criteria:
Exclusion Criteria:
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The incidence of cardiac surgery-associated AKI (CSA-AKI) varies from 5% to 42%. CSA-AKI is the second most common cause of AKI in the intensive care setting (after sepsis) and is independently associated with increased morbidity and mortality.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guo-wei Tu, PhD | Contact | 86-021-64041990 | tu.guowei@zs-hospital.sh.cn | |
| Ying Su, MD | Contact | 86-021-64041990 | su.ying@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Zhe Luo, PhD | Fudan University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan hospital, Fudan university | Recruiting | Shanghai | 200032 | China |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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Blood samples are drawn before the first dialysis session after post cardiac surgery associated AKI ( initializing RRT). Blood is drawn into Vacutainer tubes containing EDTA, and immediately placed on ice and centrifuged within 1 h. All the samples are stored at -70°C until analysis.
| Up to 90 days or ICU discharge |
| Length of stay in the hospital | the length of stay in the hospital | Up to 90 days or hospital discharge |
| Adverse events | with a focus on the complications potentially related to acute kidney injury or renal-replacement therapy during the first 7 days after enrollment | Up to 90 days |
| the number of days free of renal-replacement therapy, mechanical ventilation at 28 days | the number of days free of renal-replacement therapy, mechanical ventilation at 28 days | 28 days |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |