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Volumetric capnography is an interesting and non-invasive tool for monitoring ventilation in mechanically ventilated patients. The aim of this study was to test the effect of positive pressure ventilation and different body positions on volumetric capnograms.
In this interventional study awake and healthy volunteers will be submitted to spontaneous, pressure support and control pressure ventilation using a tight nasal mask. Volumetric capnography and electrical impedance tomography (EIT) will be continuously recorded during the protocol. Different body positions were randomly tested. Analysis of global and regional distribution of ventilation using EIT will be matched with changes observed in volumetric capnography-derived parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| non-invasive ventilation | Experimental | Non-invasive positive pressure at different body positions: sitting - supine - prone - right lateral and left lateral. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| body positions | Other | positive pressure ventilation at different body positions |
|
| Measure | Description | Time Frame |
|---|---|---|
| Analysis of the changes in volumetric capnographic parameters with changes in body positioning and positive pressure ventilation. | The volunteers are breathing spontaneously with and without positive pressure support. Capnographic parameters were registered at each studied condition. | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Electrical impedance images of the distribution of ventilation with changes in body positioning and positive pressure ventilation. | The volunteers are breathing spontaneously with and without positive pressure support. Electrical impedance images were taken at each studied condition. | 4 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gerardo H Tusman, MD | Hospital Privado de Comunidad | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Privado de Comunidad | Mar del Plata | Buenos Aires | 7600 | Argentina |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19186406 | Background | Costa EL, Lima RG, Amato MB. Electrical impedance tomography. Curr Opin Crit Care. 2009 Feb;15(1):18-24. doi: 10.1097/mcc.0b013e3283220e8c. | |
| 19517259 | Background | Tusman G, Scandurra A, Bohm SH, Suarez-Sipmann F, Clara F. Model fitting of volumetric capnograms improves calculations of airway dead space and slope of phase III. J Clin Monit Comput. 2009 Aug;23(4):197-206. doi: 10.1007/s10877-009-9182-z. Epub 2009 Jun 11. |
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| ID | Term |
|---|---|
| D007040 | Hypoventilation |
| ID | Term |
|---|---|
| D012131 | Respiratory Insufficiency |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
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| ID | Term |
|---|---|
| D011187 | Posture |
| ID | Term |
|---|---|
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |