Inulin-type Fructans-rich Vegetables, Obesity, Gut Microbiota

Impact of a Diet Rich in Inulin-type Fructans Combined With Inulin Supplementation on Gut Microbiota Composition and Metabolic Parameters in Obese Patients

The purpose of the study was to evaluate the effect of a diet based on ITF-rich vegetables in combination with purified ITF supplementation on weight management, metabolic alteration and gut microbiota composition. Obese patients were treated for 3 months and several parameters were measured before and after the study period.

Inclusion Criteria:

• Body mass index > 30 kg/m²
• Caucasian
• Presence of at least one of the following comorbidity : prediabetes, diabetes, dyslipidemia, hypertension, steatosis.

Exclusion Criteria:

• Psychiatric problems or use of antipsychotic
• Consumption of antibiotics, pro/prebiotics, fibre dietary supplement, or any molecules that modifies the intestinal transit (<6 weeks)
• Pregnancy in progress or planified within 6 months
• Specific dietary practise (vegetarian, vegan,...)
• Specific dietary treatment (<6 weeks) (e.g. high protein diet)
• Type 1 diabetes
• Excessive alcohol consumption (>3 glasses/day)
• Inconclusive acceptability test (regarding the protocol of the intervention and the vegetables used in the protocol)