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One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic.
This strategy is not recommended in patients infected with multidrug-resistant organisms or difficult to treat because of a risk of bacterial persistence on the new implant.
Antibiotic pretreatment by a narrow-spectrum molecule and for which resistance acquisition is difficult might be of interest to try to reduce the inoculum and avoid contamination of the new implant.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Antibiotic pretreatment | patients having had an antibiotic pretreatment before a one-step exchange arthroplasty |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Antibiotic pretreatment | Other | a strategy with antibiotic pretreatment before one-step exchange arthroplasty in patients who bacteria responsible for the infection has been indentified (puncture, blood cultures,...) |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of Treatment Failure | Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption |
| Measure | Description | Time Frame |
|---|---|---|
| rate of use of this strategy | descriptions of patients managed with this strategy | Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption |
| rate of bacteria responsible for infection |
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Inclusion Criteria:
Exclusion Criteria:
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patients having had a antibiotic pretreatment targeted before a one step exchange arthroplasty managed at the Croix-Rousse Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Tristan Ferry, Md,PhD | HCL | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon | Lyon | 69004 | France |
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bacterial epidemiology
| Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption |