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This study will compare continuous intravenous lidocaine against single-injection transversus abdominis plane (TAP) block as a modality for postoperative analgesia in kidney transplant surgery.
This study is a non-inferiority trial designed to assess the analgesic efficacy of an intravenous (IV) lidocaine infusion against single-injection transversus abdominis plane (TAP) block in patients undergoing kidney transplant surgery. The investigators propose a study of 124 subjects randomized into two groups. The control group will receive a TAP block. The study group will receive a continuous IV lidocaine infusion. The investigators hypothesize that there will be no statistically significant difference in postoperative opioid consumption between the two groups in the first 24 hours.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TAP Block | Active Comparator | Single-injection transversus abdominis plane block |
|
| IV Lidocaine | Active Comparator | Continuous intravenous lidocaine infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transversus Abdominis Plane Block | Procedure | Single-injection transversus abdominis plane block with 30 mL of 0.25% Bupivacaine with 1:400,000 epinephrine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Opioid Consumption | Total opioid utilization | 0-24 Hours |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Scores | Numerical Rating Scale Pain Scores (Range: 0-10, where 0 is no pain and 10 is the worst pain) | 0-48 Hours |
| Opioid Consumption | Total opioid utilization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Neil A Hanson, MD | Contact | 206-223-6980 | neil.hanson@virginiamason.org | |
| Wyndam M Strodtbeck, MD | Contact | 206-223-6980 | wyndam.strodtbeck@virginiamason.org |
| Name | Affiliation | Role |
|---|---|---|
| Neil A Hanson, MD | Virginia Mason Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Virginia Mason Medical Center | Recruiting | Seattle | Washington | 98101 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34417343 | Derived | Hanson NA, Strunk J, Saunders G, Cowan NG, Brandenberger J, Kuhr CS, Oryhan C, Warren DT, Slee AE, Strodtbeck W. Comparison of continuous intravenous lidocaine versus transversus abdominis plane block for kidney transplant surgery: a randomized, non-inferiority trial. Reg Anesth Pain Med. 2021 Nov;46(11):955-959. doi: 10.1136/rapm-2021-102973. Epub 2021 Aug 20. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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|
| Intravenous Lidocaine | Drug | Continuous intravenous lidocaine infusion |
|
|
| 24-48 Hours |
| Opioid-Related Adverse Events | Nausea, Vomiting, Pruritis, Respiratory Depression, Constipation | 0-48 Hours |
| Block/Infusion-Related Adverse Events | Local Anesthetic Systemic Toxicity | 0-48 Hours |
| Opioid Usage | Use of prescribed opioids | 30 days from discharge |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |