Repeated-dose Behavioral Intervention to Reduce Opioid Overdose

Repeated-dose Behavioral Intervention to Reduce Opioid Overdose: A Two-Site Randomized-Controlled Efficacy Trial (REBOOT)

REBOOT is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients with opioid use disorder. It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the efficacy of REBOOT vs attention-control.

Inclusion Criteria:

• Age 18-65 years
• Characteristics of opioid use history
• Previously received take-home naloxone
• No life-threatening illness likely to progress clinically during trial
• Able/willing to provide informed consent and locator information, communicate in English, and adhere to visit schedule

Exclusion Criteria:

• Suicidal ideation
• Participating in another interventional study that could possibly impact the study's outcomes of interest
• Planning to leave San Francisco/Boston metro area during study
• Previously exposed to REBOOT counseling intervention
• Any condition that, in the Principal Investigator's judgment, interferes with safe study participation or adherence to study procedures