Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

REBOOT is a pilot randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients (REBOOT). It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the feasibility of an efficacy trial of REBOOT vs treatment as usual (information and referrals) that will evaluate overdose events (non-fatal or death), drug use cessation, and overdose and HIV risk behaviors, among opioid-dependent persons who have previously overdosed and already received take-home naloxone (the opioid antagonist used to reverse overdose).

Inclusion Criteria:

• age 18-65 years;
• current opioid dependence by SCID
• urine positive for opioids during screening, excluding prescribed agonist maintenance therapy
• history of prior opioid overdose
• previously received take-home naloxone
• no serious illnesses likely to progress clinically during trial
• able and willing to provide informed consent, provide locator information, communicate in English, adhere to visit schedule

Exclusion Criteria:

• suicidal ideation by concise health risk tracking (CHRT)
• currently participating in another interventional research study that could possible impact the study's outcomes of interest
• any condition that, in the Principal Investigator's judgment, interferes with safe study participation or adherence to study procedures