Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces

Comparison of Structural and Molecular Genetic Properties Between Normal and Hypospadic Children's Prepuces

The aim of this study is to compare prepuce tissue samples from healthy male children who applied for circumcision and children with isolated hypospadias. Estrogen receptor 1 (ER1), androgen receptor (AR), FGFR2, transforming growth factor beta (TGF beta) and HOXA13 gene expression in the prepuce is planned to investigate via polymerase chain reaction (PCR) method. Mucosal vascular and nerve densities, and extracellular matrix density of laminin and collagen protein is planned to investigate via immunohistochemical examination.

Inclusion Criteria:

• To apply for circumcision, not to have any genitourinary abnormalities/conditions for control group.
• To have isolated hypospadias for study group.

Exclusion Criteria:

• To have genitourinary surgery before.