Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Proximal hypospadias (penoscrotal, scrotal, and perineal types) account for approximately 20% of all cases . The management of hypospadias has greatly improved over the past two decades since the introduction of tubularized incisized plate urethroplasty. However, obtaining a favorable cosmetic outcome and functional straight penis is a major surgical challenge for such patients, and the ideal repair of proximal hypospadias remains the Holy Grail for hypospadias specialists.
The surgical plan for proximal hypospadias can be divided into single and staged operations. Single stage operations are often associated with high rates of complications and reoperations. Reportedly, complications occur in 20-50% of patients. Therefore, many pediatric surgeons are selecting staged procedures. Staged surgical repair of proximal forms of hypospadias has been proven to achieve successful both functional and cosmetic results. Although staged repair with inner preputial layer graft has regained popularity in the repair of proximal hypospadias; but Choosing between flaps or grafts to substitute the urethral plate in 2-stage hypospadias repair has been a matter of debate with no consensus in the literature.
Flaps have reliable blood supply that may be theoretically less liable for strictures or contractures. Grafts are more versatile, which can be used in primary and recurrent cases when healthy local skin is deficient.
In this study, our aim is to compare outcomes of grafts and flaps when used to substitute the urethral plate in two-stage repair of primary proximal penile hypospadias (penoscrotal and scrotal types).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| inner preputial graft | Active Comparator | managemet of proximal penile hypospadias in 2stage using inner preputial graft in the first stage |
|
| transverse preputial island flap | Active Comparator | managemet of proximal penile hypospadias in 2stage using transverse preputial island flap in the first stage |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| inner preputial graft versus transverse preputial island flap in two-stage repair of proximal penile hypospadias | Procedure | compare outcomes of inner preputial graft versus transverse preputial island flap when used to substitute the urethral plate in two-stage repair of primary proximal penile hypospadias . |
| Measure | Description | Time Frame |
|---|---|---|
| measure complications after staged repair of proximal penile hypospadias using different techniques. | urinary fistulas, urethral strictures, diverticula and failed repair. | 6 month after end of treatment |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
outcomes of graft versus flap in management of proximal penile hypospadius
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| ahmed abohammady, denominator | Contact | 01016631447 | ahmedshaban71992@gmail.com | |
| hazem elmoghazy, professor | Contact | 01096522289 | moghazyh@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| mohamed diaa, professor | Sohag University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag Faculty of Medicine | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19995686 | Result | Kojima Y, Kohri K, Hayashi Y. Genetic pathway of external genitalia formation and molecular etiology of hypospadias. J Pediatr Urol. 2010 Aug;6(4):346-54. doi: 10.1016/j.jpurol.2009.11.007. Epub 2009 Dec 7. | |
| 26613581 | Result | Bouty A, Ayers KL, Pask A, Heloury Y, Sinclair AH. The Genetic and Environmental Factors Underlying Hypospadias. Sex Dev. 2015;9(5):239-259. doi: 10.1159/000441988. Epub 2015 Nov 28. |
| Label | URL |
|---|---|
| Genetic pathway of external genitalia formation and molecular etiology of hypospadias | View source |
Not provided
Report the cosmotic and functional outcomes after staged repair of proximal penile hypospadias using different techniques.
Not provided
Not provided
Not provided
Not provided
Not provided
Inlay inner preputial graft versus Transverse preputial island flap in management of proximal penile hypospadias
Not provided
Not provided
Not provided
|
|
| 18419998 | Result | Hsieh MH, Breyer BN, Eisenberg ML, Baskin LS. Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption. Curr Urol Rep. 2008 Mar;9(2):137-42. doi: 10.1007/s11934-008-0025-0. |
| The Genetic and Environmental Factors Underlying Hypospadias | View source |
| Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption | View source |