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Compare 0.05 μg/kg/min Norepinephrine and 0.25 μg/kg/min phenylephrine effect on fetus and parturient during Cesarean Section
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 Elements | Experimental | Continuously infusion of 0.05ug/kg/min Norepinephrine during the Cesarean Section operation |
|
| Group 2 Elements | Experimental | Continuously infusion of 0.25ug/kg/min phenylephrine during the Cesarean Section operation |
|
| Group 3 Elements | Placebo Comparator | In the placebo-control group, 3 ml/kg/min of LR was administrated according to standard weight. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Norepinephrine | Drug | 0.05ug/kg/min Norepinephrine during Cesarean Section Operation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure (SBP) change as the one of hemodynamic outcome in general monitoring | Systolic blood pressure (SBP) | through study completion, an average of 24 hour |
| Diastolic blood pressure (DBP) change as the one of hemodynamic outcome in general monitoring | Diastolic blood pressure (DBP) | Through study completion |
| Mean arterial pressure (MAP) change as the one of hemodynamic outcome in general monitoring | Mean arterial pressure (MAP) | An average of 24 hour |
| Heart rate (HR) change as the one of hemodynamic outcome in general monitoring | Heart rate (HR) | Through the study completion, an average of 24 hour |
| Stroke volume (SV) as the part of LIDICO-rapid monitoring parameter for parturient | Stroke volume (SV) | Through study completion, an average of 24 hour |
| Cardiac output (CO) as the part of LIDICO-rapid monitoring parameter for parturient | Cardiac output (CO) | Through study completion, an average of 24 hour |
| Systemic vascular resistance (SVR) as the part of LIDICO-rapid monitoring parameter for parturient | Systemic vascular resistance (SVR) | Through study completion, an average of 24 hour |
| Measure | Description | Time Frame |
|---|---|---|
| The benefits to the fetus based on umbilical vein (UV) blood gas | The umbilical vein (UV) blood gas | Through study completion, an average of 24 hour |
| The benefits to the fetus based on umbilical artery (UA) blood gas |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tianlong Wang, MD,PHD | Xuanwu Hospital, Beijing | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuanwu Hospital | Beijing | Beijing Municipality | 100053 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32894044 | Derived | Feng K, Wang X, Feng X, Zhang J, Xiao W, Wang F, Zhou Q, Wang T. Effects of continuous infusion of phenylephrine vs. norepinephrine on parturients and fetuses under LiDCOrapid monitoring: a randomized, double-blind, placebo-controlled study. BMC Anesthesiol. 2020 Sep 7;20(1):229. doi: 10.1186/s12871-020-01145-0. |
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| ID | Term |
|---|---|
| D009638 | Norepinephrine |
| D008672 | Metals, Alkali |
| D010656 | Phenylephrine |
| D008673 | Metals, Alkaline Earth |
| D000077331 | Ringer's Solution |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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| Phenylephrine | Drug | 0.25ug/kg/min phenylephrine during Cesarean Section Operation |
|
|
| Ringer's Solution | Drug | 3 ml/kg/min of LR was administrated according to standard weight. |
|
|
The umbilical artery (UA) blood gas
| Through study completion, an average of 24 hour |
| The benefits to parturient based on peripheral vein (PV) blood gas | Peripheral vein (PV) blood gas | Through study completion, an average of 24 hour |
| D000588 |
| Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |