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This clinical trial is being conducted to compare the efficacy and safety of two standard methods of polypectomy，Conventional Endoscopic Mucosal Resection（EMR）and Underwater Endoscopic Mucosal Resection（UEMR），for small colorectal polyps.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Underwater EMR | Experimental | The patients who are randomized to the " Underwater EMR" arm polypectomy with water will be performed under full water emersion without the use of submucosal injection. |
|
| Traditional EMR | No Intervention | The patients who are randomized to the " Traditional EMR" arm polypectomy will be performed with selective saline injection to the layer of tissue underneath the polyp in order to create a "safety cushion" for resection. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Underwater EMR | Behavioral | Polypectomy is performed under full water emersion without the use of submucosal injection. |
|
| Measure | Description | Time Frame |
|---|---|---|
| complete resection rate | complete resection rate is defined as a complete en bloc resection of a lesion with tumor-free lateral and vertical margins. | 7 days |
| En bloc resection rate | En bloc resection rate was defined as the entire lesion could be removed in 1 piece instead of piecemeal resection. | immediately |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse event rate | Including bleeding and perforation , etc. | 14 days |
| Procedure time | Time to execute the program | 24 hours |
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Inclusion Criteria:
Patients age between 18-75 years old with non-pedunculated colonic polyps (measuring between 4 and 9mm), who willing to participate in this study.
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Gastroenterology, Haishu No.2 Hospital, Ningbo, China | Ningbo | Zhejiang | 315000 | China | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32967616 | Derived | Zhang Z, Xia Y, Cui H, Yuan X, Wang C, Xie J, Tong Y, Wang W, Xu L. Underwater versus conventional endoscopic mucosal resection for small size non-pedunculated colorectal polyps: a randomized controlled trial : (UEMR vs. CEMR for small size non-pedunculated colorectal polyps). BMC Gastroenterol. 2020 Sep 23;20(1):311. doi: 10.1186/s12876-020-01457-y. |
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| ID | Term |
|---|---|
| D003111 | Colonic Polyps |
| ID | Term |
|---|---|
| D007417 | Intestinal Polyps |
| D011127 | Polyps |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Department of Gastroenterology, Ninghai No.2 Hospital, Ningbo, China |
| Ningbo |
| Zhejiang |
| 315000 |
| China |
| Ningbo first hospital | Ningbo | Zhejiang | 315010 | China |