UEMR Versus HSP in the Treatment of Pedunculated Colorectal Polyps Less Than 10mm in Size

Underwater Endoscopic Mucosal Resection Versus Hot Snare Polypectomy in the Treatment of Pedunculated Colorectal Polyps Less Than 10mm in Size: A Single-center, Open-label, Randomized Controlled Trial

A prospective, single-center, open-label, randomized controlled study to compare the effectiveness and safety of underwater endoscopic mucosal resection (UEMR) and hot snare polypectomy (HSP) in treating Pedunculated colorectal polyps less than 10mm in size.

1. Patients are undergone screening, surveillance, or therapeutic colonoscopy at the Endoscopy department of Gastrointestinal endoscopy center of Huadong hospital affiliated to Fudan University.
2. Randomize patients with pedunculated colorectal polyps less than 10mm in size into 2 interventional groups based on Random function of Statistical Package for the Social Sciences (SPSS) 20.0, including (1) Group 1: Underwater endoscopic mucosal resection (UEMR) and (2) Group 2: Hot snare polypectomy (HSP).
3. Collecting variables which consist of primary and secodary outcomes.

Inclusion Criteria:

• Aged between 35 and 80 years
• Pedunculated colorectal polyps less than 10mm in size in screening, surveillance or therapeutic colonoscopy
• 0-Isp or 0-Ip according to Paris classification
• Patients must sign an informed consent form prior to registration in study

Exclusion Criteria:

• Unsuitable for removal by UEMR or HSP
• Suspected malignancy
• History of inflammatory bowel disease or colorectal resection
• Familial adenomatous polyposis or Lynch syndrome
• Patients taking anticoagulant and antiplatelet agents before the examination
• Inadequate bowel preparation, defined as a Boston Bowel Preparation Scale score < 6
• ASA >=3
• Pregnancy or breastfeeding
• Severe comorbid disease involving the heart, lungs, liver, or kidneys.
• Concurrent serious conditions, including other active malignancies or severe infectious diseases