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This study evaluates the effect of 5Hz repetitive Transcranial Magnetic Stimulation (rTMS) on Dorsomedial Prefrontal Cortex on Borderline Personality Disorder (BPD).
Borderline Personality Disorder (BPD) is a mental illness with a high worldwide prevalence and economic costs, and is characterized with impulsiveness, both interpersonal relationships and emotional disturbance. Symptoms are related to hypofunction of frontal areas like Dorsomedial Prefrontal Cortex (DMPFC). Psychotherapy is the base treatment in this disease, but economic costs and long-time therapy have made difficult the attachment. Repetitive Transcranial Magnetic Stimulation(rTMS), authorized by Food and Drug Administration (FDA) on Major Depressive Disorder (MDD) treatment has proven good results in previous works in BPD clinical characteristics on both dorsolateral prefrontal cortex (DLPFC) and enhancement in depressive symptoms stimulating DMPFC in high frequency. However, there are no current research that have addressed the use of low-frequency on this anatomical area.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 5 Hz Stimulation | Active Comparator | This group will receive 5Hz (Hertz) Dorsomedial Prefrontal Cortex repetitive Transcranial Magnetic Stimulation with 1500 pulses per session, once per weekday, with a final result of 15 sessions in this modality. |
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| Placebo Stimulation | Placebo Comparator | This group will receive the Sham modality simulating 1500 pulses of 5Hz Transcranial Magnetic Stimulation for 15 sessions, one per weekday. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive Transcranial Magnetic Stimulation | Device | Subjects will receive both active and placebo rTMS, in a crossover modality. |
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| Measure | Description | Time Frame |
|---|---|---|
| Borderline Symptoms List (BSL) | BSL is a 23 item scale that evaluates the general symptoms and 11 items with behavioural evaluation of BPD. | 6 weeks |
| Global Clinical Impression of BPD (GCI-BPD) | CGI-BPD is a 10 item evaluation that rates the severity of BPD distributed in 9 neuropsychological domains with a final global score. | 6 weeks |
| Borderline Evaluation of Severity Over Time (BEST) | BEST is a 15 item scale that evaluates the severity in this pathology according to 3 areas: thoughts, emotions and typical behaviours. | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Hamilton Depression Rating Scale (HDRS) | HDRS is a 21 item scale that evaluates the severity of depressive symptoms in patients. | 6 weeks |
| Hamilton Anxiety Rating Scale (HARS) | HARS is a 14 items rating scale that evaluates the severity of anxiety symptoms in patients. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Angel R Calderón-Moctezuma, Physician | Contact | +52 9511047213 | angel_roman_cm@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Julian V Reyes-López, Psychiatrist | Faculty of Medicine, Autonomous University of Queretaro | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Autonomous University of Queretaro | Recruiting | Querétaro City | Querétaro | 76176 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32876128 | Derived | Calderon-Moctezuma AR, Reyes-Lopez JV, Rodriguez-Valdes R, Barbosa-Luna M, Ricardo-Garcell J, Espino-Cortes M, Hernandez-Chan N, Garcia-Noguez L, Roque-Roque G, Trejo-Cruz G, Canizares-Gomez S, Hernandez-Montiel H. Improvement in borderline personality disorder symptomatology after repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex: preliminary results. Braz J Psychiatry. 2021 Feb 1;43(1):65-69. doi: 10.1590/1516-4446-2019-0591. eCollection 2020. |
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| ID | Term |
|---|---|
| D001883 | Borderline Personality Disorder |
| D010554 | Personality Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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The aim of this study is to evaluate the clinical effects of 5Hz rTMS over Dorsomedial Prefrontal Cortex on an active versus placebo modality stimulation.
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Single
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| 6 weeks |
| Barratt Impulsivity Scale (BIS-11) | The Barratt Impulsiveness Scale is a questionnaire designed to assess the personality / behavioral construct of impulsiveness; composed of 30 items describing common impulsive or non-impulsive (for reversed scored items) behaviors and preferences . | 6 weeks |