Part of this study is looking at the effect of reSET on substance use. This will be measured by participant self-report on the Timeline Follow Back Questionnaire (TLFB). The TLFB is a self-report measure that gages the participant's memory by using a calendar to assess drug use within a specific period of time. The number of endorsed drugs used (as indicated by the participant) will be counted and recorded for each research visit.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as cravings to use drugs. This is captured in the reSET app as part of the programmed surveys that participants are asked to complete once pinged by the app. These surveys utilize a likert scale to ask the participant if they have experienced any cravings and the severity of said cravings (1 = mild cravings; 4=severe cravings). These ratings will assess total number of cravings and severity of cravings for the duration of the study (24 weeks) or up until the participant stops using the app; whichever comes first.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as overall mental health symptoms as measured by participant self-report on the Kessler 10 (K-10). The K-10 is a 10 item questionnaire that yields a global measure of distress based on questions about anxiety and depressive symptoms that an individual has experience within the most recent four week period. The questionnaire uses a likert scale for each prompt; a score of one indicates that an individual experiences symptoms or issues "None of the time," whereas a score of five indicates that an individual experiences symptoms or issues "All of time." The scores are summed and total amounts will fall in one of four categories: Score under 20 = likely to be well; Score 20-24 = likely to have a mild mental disorder; Score 25-29 = likely to have a moderate mental disorder; and Score 30 or more = likely to have a severe mental disorder.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as mental health specific to depression as measured by the participant self-report on the Patient Health Questionnaire (PHQ-9). The PHQ-9 is a 9 item questionnaire that assesses depressive symptoms or issues using a likert scale from "0 to 3;" 0 indicating no symptoms or issues and 3 indicating symptoms or issues occurring nearly every day. Scores are summed to calculate a total score. Scores 1-4 indicated minimal depression; scores 5-9 indicate mild depression; scores 10-14 indicate moderate depression; scores 15-19 indicated moderately severe depression; and scores 20-27 indicate severe depression.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as mental health specific to post-traumatic stress disorder as measured by the participant self-report on the abbreviated PTSD Checklist-Civilian Version (PCL-C). The PCL-C is a 17 item questionnaire that assesses PTSD symptoms on a likert scale from one to five (one = no symptoms or issues; five = extreme symptoms or issues). The scores are summed and a score of 30 or more indicates clinical PTSD symptoms.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as health status as measured by the participant self-report on the EuroQol (EQ-5D-5L). The EQ-5D-5L is a 5 item questionnaire that assesses five separate subscales including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each subscale is rated on a 1-5 likert scale (1 =no problems; 5= extremely severe problem). Data will be combined into two categories consisting of "no problem" (scores of 0) and "problems" (scores 2-5) to establish frequency counts of health status for the duration of the study.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as coping strategies as measured by the participant self-report on the Coping Strategies Scale (CSS). The CSS is 24 item questionnaire that assesses individual coping skill use on a likert scale ranging from 1-4 (1 = never use the identified coping skill; 4 = frequently use identified coping skill). A total score will be derived by taking the average of all 24 items.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as social functioning as measured by the participant self-report on the Social Connectedness Scale (SCS). The SCS is a 20 item questionnaire that assesses psychological belonging or interpersonal closeness using a likert scale ranging from 1 to 6 (1= strongly disagree; 6 = strongly agree. A total average across all items and higher scores indicate optimal functioning and a strong sense of belongingness, while lower scores reflect a lack of strong sense of belongingness.

Part of this study is looking at the effect of reSET on 6 month adherence and mediation of improvements in quality of life outcomes such as sexual health as measured by the HIV Risk Assessment (Sexual Experience and Risk Behavior Assessment - SERBAS). The SERBAS elicits counts of protected and unprotected vaginal or anal sex occasions by partner type.

This study will also be measuring patient satisfaction with the reSET app. This will be measured by an investigator created qualitative interview assessing the patient's likes, dislikes, and ease of use with the app, as well as open ended questions regarding how the patient would improve the app. This data will be uploaded into a qualitative system such as Nvivo for analysis.

This study will also measure the effectiveness of the reSET app from the participant's stand point. This will be measured using The Intervention Acceptability/ Feedback Form (IAFF). The IAFF is a 9 item questionnaire. Seven questions evaluate the content of the app through the use of a likert scale ranging from 0 to 10 where 0 indicates the lowest effectiveness of the content and 10 indicates highest effectiveness of the content (i.e.: usefulness, relevancy, interesting, novelty, ease of understanding, and satisfaction as related to the app content). Two open ended questions allow the participant to address additional likes and dislikes with the content, as well as suggestions on improving the content. Frequency counts will be used to analyze likert scale scores, while responses to open ended questions will be uploaded into a qualitative system such as Nvivo for analysis.