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| ID | Type | Description | Link |
|---|---|---|---|
| KCT0003707 | Other Identifier | Clinical Research Information Service, Republic of Korea |
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| Name | Class |
|---|---|
| Ulsan University Hospital | OTHER |
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This study is a retrospective cohort study. The purpose of this study is to investigate clinical features of the patients with the cavitary pulmonary tuberculosis (TB) and endobronchial TB from the patients who have been registered in this hospital for treatment and follow-up, as part of the "PPM Project (Private-Public Mix project) for Korean National Tuberculosis Control" introduced in Korea since 2007.
Cavitary pulmonary tuberculosis (TB) is known to remain its Infectivity for a longer period of time than the non-cavitary pulmonary TB, which is usually almost inactivated its infectivity within two weeks after the administration of the anti - TB drugs.
However, there are few studies on this, so it is not known how long the infectivity persists, whether there is a correlation with the number of cavities or the size of the cavities between persistence of infectivity.
Meanwhile, endobronchial TB is known also to be highly infectious, unlike simple pulmonary TB.
It is not known how long infectivity can persist after the administration of anti-TB medication, and whether there is any difference in persistence of infectivity regarding the clinical characteristics of endobronchial TB.
In this study, investigators will analyze the retrospective data analysis of UUH-PPM Cohort, a cohort of PPM project patients in the Ulsan University Hospital (UUH).
The PPM project is a "Private-Public Mix project" for the eradication of tuberculosis from Korea, which the Korean government and private medical institutions have been conducting since 2007.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cavitary Pulmonary Tuberculosis | The patients who are diagnosed with the cavitary pulmonary tuberculosis |
| |
| Endobronchial Tuberculosis | The patients who are diagnosed with the endobronchial tuberculosis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observation of AFB smear/culture | Other | Observation of the patients from group for their AFB smear/culture results |
|
| Measure | Description | Time Frame |
|---|---|---|
| TLSD | Treatment of anti-TB medication to Last Smear positive Duration | at baseline |
| TLCD | Treatment of anti-TB medication to Last Culture positive Duration | at baseline |
| ACSD | AFB Culture-Smear positive Dissociation | at baseline |
| TCV/RLV | TCV/RLV (Total Cavity[ies] Volume/Total Lung Volume) on enhance CT | at baseline |
| TTV/RLV | TTV/RLV (Total TB lesion Volume/Total Lung Volume) on enhance CT | at baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Radiological measure for Tb lesions including cavity size, number | analysis by BioView Duet Workstation (BioView Ltd, Rehovot, Israel) [cavitary pulmonary TB] | at baseline |
| Admission Duration |
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A. Cavitary Pulmonary TB Group
Inclusion Criteria:
Exclusion Criteria:
B. Endobronchial TB Group
Inclusion Criteria:
Exclusion Criteria:
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The patients who have been registered in this hospital for treatment and follow-up, as part of the "PPM Project (Private-Public Mix project) for Korean National Tuberculosis Control" introduced in Korea since 2007.
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| Name | Affiliation | Role |
|---|---|---|
| Kwang Won Seo, M.D., Ph.D. | Ulsan University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ulsan University Hospital, 877 Bangeojin Sunwhando-ro | Ulsan | 44033 | South Korea |
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The patients' Hospital admission duration [cavitary pulmonary TB and endobronchial TB]
| at baseline |
| Isolation Duration | The patients' isolation duration during hospital admission [cavitary pulmonary TB and endobronchial TB] | at baseline |
| Hemoptysis /Bronchial artery embolization (BAE) | The patients' history of Hemoptysis /Bronchial artery embolization (BAE) [cavitary pulmonary TB and endobronchial TB] | at baseline |
| TB PCR, XPERT | The patients' result of TB PCR, XPERT [cavitary pulmonary TB and endobronchial TB] | at baseline |
| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| D014397 | Tuberculosis, Pulmonary |
| D018088 | Tuberculosis, Multidrug-Resistant |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D046508 | Culture Techniques |
| ID | Term |
|---|---|
| D066298 | In Vitro Techniques |
| D008919 | Investigative Techniques |
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