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| ID | Type | Description | Link |
|---|---|---|---|
| 2018R1C1B5085364 | Other Grant/Funding Number | National Research Foundation of Korea |
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This study investigates the utility of thin bronchoscope and virtual bronchoscopic navigation system (targeted bronchial washing) for detection of M. tuberculosis and resistant-conferring mutations in patients with pulmonary tuberculosis. Time to appropriate treatment and stain/culture conversion are also evaluated.
Comparisons of detection rate of M. tuberculosis and resistant-conferring mutations between patients who perform CT-guided conventional bronchoscope and patients who perform VBN-guided thin bronchoscope.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional arm | No Intervention | Perform bronchial washing using conventional methods.
| |
| Investigational arm | Active Comparator | Perform bronchial washing using investigational methods.
|
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thin bronchoscope and VBN | Device | targeted washing at more adjacent TB lesion using thin bronchoscope and virtual bronchoscopic navigation system |
|
| Measure | Description | Time Frame |
|---|---|---|
| detection of M. tuberculosis and resistant-conferring mutations | evaulation by sensitivity, specificity, PPV and NPV | 2months after procedure |
| Measure | Description | Time Frame |
|---|---|---|
| time to appropriate treatment and stain/culture conversion | date of treatment initiation and stain/culture negative conversion | 6months after procedure |
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Inclusion Criteria:
Exclusion Criteria:
persons who do not agree with bronchoscopy (persons who want empirical treatment for TB)
persons with contraindications for bronchoscopy
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| Name | Affiliation | Role |
|---|---|---|
| Jeongha Mok, MD, PhD | Pusan National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pusan National University Hospital | Busan | 49241 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36151949 | Derived | Eom JS, Park S, Jang H, Kim S, Yoo WH, Kim SH, Mok J. Bronchial Washing Using a Thin Versus a Thick Bronchoscope to Diagnose Pulmonary Tuberculosis: A Randomized Trial. Clin Infect Dis. 2023 Jan 13;76(2):238-244. doi: 10.1093/cid/ciac789. |
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| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |