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| ID | Type | Description | Link |
|---|---|---|---|
| UCD#3565 | Other Identifier | University of CA Davis Psychiatry |
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The purpose of this study is to better understand the neural correlates of higher-order cognition, both in the healthy brain and in schizophrenia, and to determine how these mechanisms are modulated by transcranial direct current stimulation (tDCS) at frontal and occipital scalp sites. Testing the effects of tDCS at these scalp sites on cognitive task performance will help us understand the roles of the brain regions corresponding to these sites during higher-order cognitive processing (language comprehension, cognitive control, and related attention and memory processes). Behavioral and electrophysiological (EEG) measures will be used to assess cognitive performance. The investigator's overarching hypothesis is that stimulating prefrontal circuits with tDCS can improve cognitive control performance, and ultimately performance on a range of cognitive tasks, as compared to stimulating a different cortical region (occipital cortex) or using sham stimulation. This study is solely intended as basic research in order to understand brain function in healthy individuals and individuals with schizophrenia. This study is not intended to diagnose, cure or treat schizophrenia or any other disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DLPFC Stimulation | Experimental | Intervention. 20 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex. |
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| Occipital Stimulation | Active Comparator | Intervention. 20 minutes of 2 mA direct current stimulation over the occipital cortex. |
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| Sham Stimulation | Sham Comparator | Placebo Comparator. 0.5-1 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex followed by 19-19.5 minutes of sham stimulation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulation | Device | In tDCS, saline-soaked electrodes are temporary affixed to the scalp and connected to a battery-powered current generator. A weak (2 mA) constant current is then briefly applied (~20 minutes) to stimulate the targeted brain area (e.g. the DLPFC). To control for placebo effects, the study will utilize a sham stimulation protocol that consists of very brief constant stimulation (~1 minute). Subjects usually cannot discern the difference between the sham and experimental stimulation protocols due to habituation. |
| Measure | Description | Time Frame |
|---|---|---|
| EEG Correlates of Language and Cognitive Control | Electrophysiological data recorded during completion of cognitive control and language comprehension tasks. We will measure oscillatory activity in the theta, alpha, beta and gamma frequency bands. | Assessment will begin immediately following stimulation and last for about 1.5 hours. |
| Behavioral Response (Cognitive Control Task) | We will assess performance on the Dot Pattern Expectancy (DPX) task (error rates and d-prime scores). | Assessment will begin immediately following stimulation and last for about 1.5 hours. |
| Behavioral Response (Language Task) | We will assess performance on a novel Language Comprehension task (accuracy and semantic relatedness judgement scores). | Assessment will begin immediately following stimulation and last for about 1.5 hours. |
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Inclusion Criteria:
Inclusion Criteria for Patients with Schizophrenia Only:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Imaging Research Center | Sacramento | California | 95817 | United States |
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| Label | URL |
|---|---|
| Learn more or sign up for the study here! | View source |
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Select data from this study may be submitted to the National Institute of Mental Health Data Archive (NDA). NDA is a data repository run by the National Institute of Mental Health (NIMH) that allows researchers studying mental illness to collect and share de-identified information with each other. The data repository is accessible only to qualified investigators. All subject data will be de-identified (subject names will not be used) and each subject will have a separate identifier called a Global Unique Identifier (GUID) to remove any possibility that "the identities of the subjects cannot be readily ascertained or otherwise associated with the data by the repository staff or secondary data users." (45 CFR, 46.102).
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 18, 2026 | Apr 7, 2026 | 16 | ||
| May 26, 2026 |
| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D007802 | Language |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D003142 | Communication |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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|
| Jun 22, 2026 |
| 17 |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |