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The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of ischemic stroke patients.
This study aims to detect the impact of probiotics administration during the process of ischemic stroke treatment and recovery phase. The day of admission and 3months after stroke data will be collected and put into analysis to provide some suggestions on the probiotics use in the clinical for the stroke patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Intervention | No Intervention | the patients in this arm will not receive probiotics. | |
| Experimental | Experimental | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus for 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotics | Dietary Supplement | the patients in this arm will receive probiotics blend of Bifidobacterium longum, Lactobacillus acidophilus,Bifidobacterium lactobacillus,Lactobacillus paracasei,Lactobacillus rhamnosus and Lactobacillus fermentium with does of 8*10^9 Colony-Forming Units(CFU) *2/d for 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| change from admission on gut microbiome at 3months by genome sequencing | change of the gut microbiome will be calculated at 3months in comparison with admission. | 3months |
| Measure | Description | Time Frame |
|---|---|---|
| change from admission on cognitive function at 3months by Montreal Cognitive Assessment. | change from admission on cognitive function at 3months by Montreal Cognitive Assessment (MoCA). MoCA's score is from 0 to 30.the score is lower,the cognitive disorder is worse. | 3months |
| change from admission on emotion at 3months by Hamilton Depression Scale. |
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Inclusion Criteria:
the time from paroxysm to admission ≤2weeks.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yongqiang Liu, postgraduate | Contact | 18321785703 | 3101702346@qq.com | |
| Hao Li, MD | Contact | 1415701131@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Huanlong Qin | Shanghai 10th People's Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai 10th People's Hospital | Recruiting | Shanghai | 20072 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36897813 | Derived | Clottes P, Benech N, Dumot C, Jarraud S, Vidal H, Mechtouff L. Gut microbiota and stroke: New avenues to improve prevention and outcome. Eur J Neurol. 2023 Nov;30(11):3595-3604. doi: 10.1111/ene.15770. Epub 2023 Apr 6. |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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change from admission on emotion at 3months by Hamilton Depression Scale（HAMD） .When HAMD's score is beyond 17,the patient is considered to have minor depression.When HAMD's score is beyond 20,the patient is considered to have medium depression. When HAMD's score is beyond 30,the patient is considered to have severe depression. |
| 3months |
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D019602 |
| Food and Beverages |