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| Name | Class |
|---|---|
| Guangdong 999 Brain Hospital | OTHER |
| Zhujiang Hospital | OTHER |
| First Affiliated Hospital of Jinan University | OTHER |
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Post-stroke cognitive impairment(PSCI) is one of the most important factors causing disabilities after stroke. Recent study found that gut microbiota plays a key role in neurological diseases. Two recent small sample studies reported gut dysbiosis in PSCI patients. In order to further verify the relationship between PSCI and gut microbiota and the predictive value of gut microbiota and serum markers for cognitive impairment and poor prognosis after ischemic stroke. The study intended to collect stool specimens of patients with acute ischemic stroke and assess their cognitive psychological state, and to establish a prospective multi-center follow-up cohort to explore the correlation between the dynamic changes of intestinal flora in patients with stroke and PSCI and poor prognosis of stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ischemic stroke | Patients with ischemic stroke within 7 days of onset |
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| Measure | Description | Time Frame |
|---|---|---|
| Mini-Mental State Examination | A cognitive function screening test ranged 0-30, higher scores mean better cognitive function | 7 days after admission |
| Mini-Mental State Examination | A cognitive function screening test ranged 0-30, higher scores mean better cognitive function | 3 months after discharge |
| Mini-Mental State Examination | A cognitive function screening test ranged 0-30, higher scores mean better cognitive function | 6 months after discharge |
| Montreal Cognitive Assessment | A cognitive function screening test ranged 0-30, higher scores mean better cognitive function | 7 days after admission |
| Montreal Cognitive Assessment | A cognitive function screening test ranged 0-30, higher scores mean better cognitive function | 3 months after discharge |
| Montreal Cognitive Assessment | A cognitive function screening test ranged 0-30, higher scores mean better cognitive function | 6 months after discharge |
| Gut microbiota | Results of fecal bacteria by 16s RNA sequencing | 2 days after admission |
| Gut microbiota |
| Measure | Description | Time Frame |
|---|---|---|
| Modified Rankin Scale(mRS) | A neurological function score scale ranged 0-6, higher scores mean worse neurological outcome | 7 days after admission |
| Modified Rankin Scale(mRS) | A neurological function score scale ranged 0-6, higher scores mean worse neurological outcome |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with ischemic stroke within 7 days of onset
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yin Jia, Master | Contact | +86 13802964883 | jiajiayin@139.com | |
| Zhang Mingsi, Master | Contact | +86 13827003570 | meens19@qq.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology, NanFang Hospital, Southern Medical University | Recruiting | Guanzhou | Guangdong | 510515 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37875813 | Derived | Ren Y, Liang J, Li X, Deng Y, Cheng S, Wu Q, Song W, He Y, Zhu J, Zhang X, Zhou H, Yin J. Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients. BMC Microbiol. 2023 Oct 24;23(1):305. doi: 10.1186/s12866-023-03057-8. |
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| ID | Term |
|---|---|
| D000083242 | Ischemic Stroke |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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blood plasm; Faeces ;Oral swabs
Results of fecal bacteria by 16s RNA sequencing |
| 3 months after discharge |
| 3 months after discharge |
| Modified Rankin Scale(mRS) | A neurological function score scale ranged 0-6, higher scores mean worse neurological outcome | 6 months after discharge |
| Modified Rankin Scale(mRS) | A neurological function score scale ranged 0-6, higher scores mean worse neurological outcome | 12 months after discharge |
| National Institute of Health stroke scale(NIHSS) | Neurological function score scale, ranged 0-42, higher scores mean more severe neurological deficit | Day 1 of admission |
| National Institute of Health stroke scale(NIHSS) | Neurological function score scale, ranged 0-42, higher scores mean more severe neurological deficit | Day 7 of admission |
| National Institute of Health stroke scale(NIHSS) | Neurological function score scale, ranged 0-42, higher scores mean more severe neurological deficit | 3 months after discharge |
| National Institute of Health stroke scale(NIHSS) | Neurological function score scale, ranged 0-42, higher scores mean more severe neurological deficit | 6 months after discharge |
| Short chain fatty acids | A metabolites of gut microbiota from stool, detected by gas chromatography-mass spectrometry (GC-MS) combined technique | 2 days after admission |
| Short chain fatty acids | A metabolites of gut microbiota from stool, detected by gas chromatography-mass spectrometry (GC-MS) combined technique | 3 months after discharge |
| Trimethylamine-N-Oxide | A metabolites of gut microbiota in plasm, quantified by stable isotope dilution liquid chromatography tandem mass spectrometry | 2 days after admission |
| Trimethylamine-N-Oxide | A metabolites of gut microbiota in plasm, quantified by stable isotope dilution liquid chromatography tandem mass spectrometry | 3 months after discharge |
| Untargeted Metabolomics | Untargeted metabolomics refers to using gas chromatography-mass spectrometry (GC-MS) combined technique, without bias detection of all small molecule metabolites in plasma (mainly the relative molecular weight of 1000 Da endogenous small molecule compounds) levels. | 2 days after admission |
| Untargeted Metabolomics | Untargeted metabolomics refers to using gas chromatography-mass spectrometry (GC-MS) combined technique, without bias detection of all small molecule metabolites in plasma (mainly the relative molecular weight of 1000 Da endogenous small molecule compounds) levels. | 3 months after discharge |
| D009422 |
| Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |