Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The concept of Enhanced Recovery After Surgery(ERAS) has been prevalent in recent years. In the ERAS guideline, short-acting anesthetics, instead of long-acting opioid anesthetics, were recommended during surgery to decrease post-operative complication and length of hospital stay. Propofol-remifentanil based total intravenous anesthesia (TIVA) can provide quicker emergence and decreased post-operative nausea and vomiting. However, the prescription of opioid (especially remifentanil) may induce opioid-induced hyperalgesia (OIH) and increase the requirement of analgesics. Previous studies provided some strategies to prevent OIH. The purpose of this study is to investigate the effect of adding remifentanil(1 mcg/kg) after emergence and endotracheal extubation in breast cancer females receiving breast surgery under propofol-remifentanil based TIVA for the prevention of OIH.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| remifentanil | Experimental | After emergence and extubation of endotracheal tube, remifentanil 1mcg/kg were diluted with 0.9% saline to 50 ml, added in IV bag, and drip for 30 minutes. |
|
| no intervention | No Intervention | After emergence and extubation of endotracheal tube, 0.9% saline 50ml were added in IV bag and drip for 30 minutes. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remifentanil | Drug | remifentanil 1mcg/kg added in 0.9% saline and diluted to 50ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| Numerical Rating Score (NRS) for pain score in post-anesthesia room (PAR) | 1.The pain after breast surgery is moderate and suppose to be reduced after combined prescription of NSAID and local analgesics. Post-operative pain is supposed to be related with hyperalgesia. 2.Record the degree of post-operative pain by Numerical Rating Scale (Numerical Rating Scale)(0-10; 0= no pain; 10=pain as bad as can be) | 0 minutes |
| Numerical Rating Score (NRS) for pain score in post-anesthesia room (PAR) | 1.The pain after breast surgery is moderate and suppose to be reduced after combined prescription of NSAID and local analgesics. Post-operative pain is supposed to be related with hyperalgesia. 2.Record the degree of post-operative pain by Numerical Rating Scale (Numerical Rating Scale)(0-10; 0= no pain; 10=pain as bad as can be) | 30 minutes |
| The amount analgesic requirement in post-anesthesia room (PAR) | 1.The pain after breast surgery is moderate and suppose to be reduced after combined prescription of NSAID and local analgesics during surgery. Post-operative pain is supposed to be related with hyperalgesia. 2.Record the degree of post-operative pain by record additional analgesics amount (rescue medication, mg) in PAR | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| degree of post-operative nausea in post-anesthesia room (PAR) | Record the degree of nausea in PAR: mild, moderate, severe | 30 minutes |
| degree of post-operative vomiting in post-anesthesia room (PAR) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
breast cancer female
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jyh-cherng Yu, MD | Tri-Service General Hospital (TSGH) | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tri-Service General Hospital | Taipei | 114 | Taiwan |
Numerical rating scale, rescue analgesic amount
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
Not provided
Not provided
Breast cancer patient
Not provided
Not provided
Not provided
Record the degree of vomiting in PAR: mild, moderate, severe
| 30 minutes |
| post-operative blood pressure in post-anesthesia room (PAR) | Record the blood pressure(mmHg) in PAR | 0 minutes |
| post-operative systolic blood pressure in post-anesthesia room (PAR) | Record the systolic blood pressure(mmHg) in PAR | 0 minutes |
| post-operative systolic blood pressure in post-anesthesia room (PAR) | Record the systolic blood pressure(mmHg) in PAR | 30 minutes |
| post-operative diastolic blood pressure in post-anesthesia room (PAR) | Record the diastolic blood pressure(mmHg) in PAR | 30 minutes |
| post-operative heart rate in post-anesthesia room (PAR) | Record the heart rate (beat/min) in PAR | 0 minutes |
| post-operative heart rate in post-anesthesia room (PAR) | Record the heart rate (beat/min) in PAR | 30 minutes |
| post-operative pulse oximeter in post-anesthesia room (PAR) | Record the pulse oximeter(SpO2; %) in PAR | 0 minutes |
| postoperative pulse oximeter in post-anesthesia room (PAR) | Record the pulse oximeter(SpO2; %) in PAR | 30 minutes |
| Numerical Rating Score (NRS) for pain score in ward | Record the degree of post-operative pain by Numerical Rating Scale (NRS)(0-10; 0= no pain; 10=pain as bad as can be) | 1 hour after transferring to ward |
| Numerical Rating Score (NRS) for pain score in ward | Record the degree of post-operative pain by Numerical Rating Scale (NRS)(0-10; 0= no pain; 10=pain as bad as can be) | 2 hours after transferring to ward |
| Numerical Rating Score (NRS) for pain score in ward | Record the degree of post-operative pain by Numerical Rating Scale (NRS)(0-10; 0= no pain; 10=pain as bad as can be) | 4 hours after transferring to ward |
| Numerical Rating Score (NRS) for pain score in ward | Record the degree of post-operative pain by Numerical Rating Scale (NRS)(0-10; 0= no pain; 10=pain as bad as can be) | 8 hours after transferring to ward |
| Numerical Rating Score (NRS) for pain score in ward | Record the degree of post-operative pain by Numerical Rating Scale (NRS)(0-10; 0= no pain; 10=pain as bad as can be) | 24 hours after transferring to ward |
| total analgesics requirement in ward | Record total analgesic requirement (mg) in ward | 24hr after transferring to ward |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |