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Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high dose remifentanil without ibuprofen | Placebo Comparator | remifentanil target-controlled infusion effect-site concentration 4 ng/ml normal saline before surgical incision |
|
| low dose remifentanil without ibuprofen | Placebo Comparator | remifentanil target-controlled infusion effect-site concentration 1 ng/ml normal saline before surgical incision |
|
| high dose remifentanil with ibuprofen | Active Comparator | remifentanil target-controlled infusion effect-site concentration 4 ng/ml Intravenous ibuprofen 800 mg before surgical incision |
|
| low dose remifentanil with ibuprofen | Active Comparator | remifentanil target-controlled infusion effect-site concentration 1 ng/ml Intravenous ibuprofen 800 mg before surgical incision |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high dose remifentanil | Drug | high dose remifentanil |
|
| Measure | Description | Time Frame |
|---|---|---|
| cumulative morphine consumption | cumulative patient-controlled analgesia (PCA) morphine consumption | postoperative 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Pain score | visual analogue scale | postoperative 1, 3, 6,12, 24, 48 hours Pain score |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D006930 | Hyperalgesia |
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D020886 | Somatosensory Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000077208 | Remifentanil |
| D007052 | Ibuprofen |
| ID | Term |
|---|---|
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Ibuprofen | Drug | intravenous ibuprofen |
|
| low dose remifentanil | Drug | low dose remifentanil |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D010146 | Pain |
| D010880 |
| Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010666 | Phenylpropionates |
| D000146 | Acids, Carbocyclic |