Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

Inclusion Criteria:

• Adult patients scheduled for elective pancreaticoduodenectomy

Exclusion Criteria:

• Patients with chronic pain
• Patients with psychiatric disease
• Patients with nonsteroidal antiinflammatory drugs allergy
• Patients with renail dysfunction
• History of drug addiction
• Pregnant patient
• Inability to use a PCA device