Gallbladder disease is one of the most common diseases of the gastrointestinal tract. Various studies have shown an association between gallstones and an alteration in the serum lipids. The objective of this study will be to compare serum lipid profile of gallstone patients with the controls.

This prospective cross-sectional study will be conducted in the Surgical Department of the Services Institute of Medical Sciences. A total of 50 patients will beincluded in the study after screening through the inclusion criteria. A control group of 50 inpatients with no personal or family history of gallstones will be also recruited for comparison. Results will be expressed as mean with standard deviation. Students t- test will be used to compare the data between the patients and the control groups (p<0.05 will be considered statistically significant). SPSS software, version 20 will be used for statistical analysis.

Inclusion Criteria:

• Male or female patients with the gall stone disease
• Age from 20 to 70 years
• Gallstones were diagnosed through the ultrasound

Exclusion Criteria:

• Patients with acalculous gallbladder disease on ultrasound,
• Patients with terminal ileal resection,
• Patients with hemolytic diseases (hereditary spherocytosis, sickle cell anemia on history and CBC film),
• Patients with liver cirrhosis (on abdominal ultrasound) and
• Patients on antihyperlipidemic drugs

Case group: patients from lahore city presented with gallstone disease in Services Hospital lahore

Control group: Patients admitted to Services Hospital with other diseases belonging from lahore