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| Name | Class |
|---|---|
| Bayer | INDUSTRY |
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The main objective of this study is to analyze a new noninvasive imaging examination, OCT angiography, in the evaluation of neovascular remodeling and early signs of recurrence of wet AMD undergoing treatment on OCTA and to correlate OCTA findings with SD-OCT findings.
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| Measure | Description | Time Frame |
|---|---|---|
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| presence of flow void on OCTA |
| Measure | Description | Time Frame |
|---|---|---|
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with wet-AMD (NVC type 1 or 2) diagnosed maximum one week before inclusion and for whom Aflibercept in intra-vitreal injection technic has been prescribed.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Pellegrin, CHU de Bordeaux | Bordeaux | 33000 | France | |||
| CHI de Créteil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41759060 | Derived | Amoroso F, Miere A, Kodjikian L, Couturier A, Korobelnik JF, Jung C, Wang X, Blanco-Garavito R, Souied EH. SD-OCT AND OCTA: Distinct or Additional Information on Neovascular Activity? The COCTAEYL Study. Retina. 2026 Jul 1;46(7):1203-1211. doi: 10.1097/IAE.0000000000004815. |
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| ID | Term |
|---|---|
| D057135 | Wet Macular Degeneration |
| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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high flow on OCTA corresponding to the neovascular network with vascular remodeling over time |
| at month 13 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 13 |
| at month 1 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of flow on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month1 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of collaterals on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of peripheral arcade on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of arteriolization on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of vascular loops on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of dark halo on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of feeder vessel on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| presence of flow void on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| measure of neovascular area on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | baseline |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 1 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 2 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 3 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 4 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 5 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 6 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 7 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 8 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 9 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 10 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 11 |
| measure of neovascular density on OCTA | high flow on OCTA corresponding to the neovascular network with vascular remodeling over time | at month 12 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 13 |
| Intraretinal and/or subretinal fluid in SD-OCT | at baseline |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 1 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 2 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 3 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 4 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 5 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 6 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 7 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 8 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 9 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 10 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 11 |
| Intraretinal and/or subretinal fluid in SD-OCT | at month 12 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at baseline |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 1 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 2 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 3 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 4 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 5 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 6 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 7 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 8 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 9 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 10 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 11 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 12 |
| visual acuity in logmar | Measure of best-corrected visual acuity (BCVA) measured on ETDRS | at month 13 |
| presence or abscence of hemorrhage, fibrosis and atrophy on fundus color photography | at 1 months |
| presence or abscence of hemorrhage on fundus color photography | at 1 months |
| presence or abscence of fibrosis on fundus color photography | at 1 months |
| presence or abscence of atrophy on fundus color photography | at 1 months |
| presence or abscence of hemorrhage on fundus color photography | at 13 months |
| presence or abscence of fibrosis on fundus color photography | at 13 months |
| presence or abscence of atrophy on fundus color photography | at 13 months |
| type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions) | Baseline |
| type of choroidal neovascularization on fluorescein angiography (type 1, type 2 or mixed lesions) | at month 13 |
| type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions) | baseline |
| type of choroidal neovascularization on indocyanine green angiography (type 1, type 2 or mixed lesions) | at month 13 |
| choroidal thickness on EDI-OCT | monthly during 13 months |
| type of choroidal neovascularization on SD-OCT (type 1, type 2 or mixed lesions) | monthly during 13 months |
| Créteil |
| 94000 |
| France |
| Hôpital La Croix Rousse | Lyon | 69004 | France |
| Hôpital Lariboisière, APHP | Paris | 75010 | France |
| Centre Ophtalmologique d'Imagerie et de Laser, | Paris | 75015 | France |