OCT Angiography in Wet AMD

Optical Coherence Tomography Angiography in Neovascular Age-related Macular Degeneration

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to:

1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD)
2. evaluate patients undergoing treatment for wet AMD
3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.

Inclusion Criteria (Groups with wet AMD):

• Adults aged 50 and older with clinical findings of treatment-naïve (never treated) neovascular AMD with active new blood vessel growth confirmed by clinical testing will be considered

Inclusion Criteria (Group with healthy eyes)

• No evidence of retinal disease
• Refractive error greater than +3.00 diopters or -7.00 diopters (glasses Rx)
• No recent eye surgery in the last 4 months
• No significant cataract to interfere with the quality of the imaging

Exclusion Criteria (All Groups):

• Inability to give informed consent
• Significant kidney disease
• Blood pressure greater than 180/110
• Previous macular laser treatment
• Inability to maintain stable fixation during OCT imaging
• Visual acuity worse than 20/200