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The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Newly-diagnosed, untreated wet AMD | This group will be adults newly diagnosed with wet AMD who have not undergone any treatment for the condition. Their data will be gathered only once, prior to treatment. |
| |
| Wet AMD undergoing "as-needed" treatment | This group will be adults undergoing treatment as-needed for wet AMD. They will be followed monthly over the course of 1 year. |
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| High-risk eyes | This group will be adults with wet AMD in one eye and findings of dry AMD in the other. The eye with dry AMD will be followed every 6 months for 3 years. |
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| Wet AMD undergoing a "treat and extend" strategy | This group will be adults with wet AMD undergoing treatment under the "treat and extend" strategy. (The "treat and extend" strategy increases the intervals between treatments as long as the macula remains dry.) They will be followed over the course of 1 year with extra imaging before extending follow-up intervals. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optical Coherence Tomography | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measure of choroidal neovascular (CNV) vessel area in mm2 | 1 year | |
| Measure of CNV membrane area in mm2 | 1 year | |
| Measure of CNV length density in mm | 1 year | |
| Measure of retinal fluid volume in mm3 | 1 year | |
| Measure of drusen area in mm2 | 3 years |
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Inclusion Criteria (Groups with wet AMD):
Inclusion Criteria (Group with healthy eyes)
Exclusion Criteria (All Groups):
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Both female and male participants over the age of 50 are being studied.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| George Pacheco, COA | Contact | 503-494-7398 | pachecge@ohsu.edu | |
| Denny Romfh, OD | Contact | 503-494-4351 | romfhd@ohsu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Steven Bailey, MD | Oregon Health and Science University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Casey Eye Institute, Oregon Health & Science University | Recruiting | Portland | Oregon | 97239 | United States |
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| ID | Term |
|---|---|
| D008268 | Macular Degeneration |
| ID | Term |
|---|---|
| D012162 | Retinal Degeneration |
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |