Genesis Electrical Impedance Tomography (EIT): A Preliminary Study

The Associations Between EIT and Clinical Measures During Standard of Care Procedures in Patients With Respiratory Disease: A Preliminary Study

The purpose of this study is to evaluate the Genesis Electrical Impedance Tomography (EIT) imaging system for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in age and height matched controls. The EIT does not use radiation, and is read through electrodes.

The purpose of this study is to evaluate EIT for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in age and height matched controls.

Researchers will use EIT to determine changes in regional ventilation with pulmonary interventions including airway clearance and invasive and noninvasive ventilation in a pediatric respiratory disease population.

Inclusion Criteria:

• 2 weeks old - 40 years old
• Premature infants with current age >2 weeks with a confirmed diagnosis of BPD based on NIH criteria
• Or Chronic respiratory disease due to underlying neuromuscular disease
• Or confirmed neuromuscular disease with an echo completed within the preceding 12 months of study participation of DMD or other diagnoses associated with mild cardiomyopathy.
• have had a VQ scan
• will be undergoing cardiac catherization for for pulmonary vein stenosis, pulmonary hypertension and/or pulmonary artery stenosis
• Or healthy controls

Exclusion Criteria:

• <2 weeks of age
• Congenital diaphragmatic hernia
• Severe congenital heart disease
• Significant genetic abnoralities
• Anything that interferes with lead placement on the chest wall
• Unwilling/refusal to sign consent
• Pregnant or lactating
• Pacemaker of other surgical implant and spinal implant (causes noise in the data)
• Moderate to severe cardiomyopathy
• Patients with temporary cognitive disability due to illness