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| ID | Type | Description | Link |
|---|---|---|---|
| 1R21EB016869-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute for Biomedical Imaging and Bioengineering (NIBIB) | NIH |
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The goal of this study is to evaluate the sensitivity and specificity of Electrical Impedance Tomography (EIT) as a bedside diagnostic tool for lung pathologies in patients who are mechanically ventilated. In electrical impedance tomography low amplitude, low frequency current is applied on electrodes, and the resulting voltage is measured and used to computed the electrical properties of the interior of the chest as they change in time. The computed properties are used to form an image, which can then be used for monitoring and diagnosis.
The goal of this study is to characterize the ability of the electrical impedance tomography system (hardware and software) to distinguish between lung pathologies by assessing the sensitivity and specificity as well as the overall agreement with the CT scan in terms of spatial resolution. The study will test, as well as refine, the mathematical algorithms needed to create meaningful outputs on adult patients receiving mechanical ventilation and who also have received or will be receiving a CT scan as part of their standard of care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mechanical ventilation | Hospitalized adult patients with lung injury receiving mechanical ventilation and who also have received or will receive a CT scan as part of their standard care |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mechanical Ventilation | Device | Subjects will receive mechanical ventilation as part of their standard of care, as specified in the enrollment criteria |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and specificity for diagnosing lung pathology | The sensitivity and specificity of EIT for the detection and identification of different types of lung pathology will be assessed with clinical diagnosis aided by CT scan as the gold standard. | One year |
| Measure | Description | Time Frame |
|---|---|---|
| Regional correlation with CT scan | The spatial correlation between the organs and lung pathology in the CT scan image in the plane of the electrodes and the EIT image will be computed. | One year |
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Inclusion Criteria:
Exclusion Criteria:
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Mechanically ventilated adult intensive care unit patients at Medical Center of the Rockies with pulmonary pathology who have received or will be receiving a CT scan as part of their standard care
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| Name | Affiliation | Role |
|---|---|---|
| Jennifer L Mueller, Ph.D. | Colorado State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical Center of the Rockies | Loveland | Colorado | 80538 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23314771 | Background | Hamilton SJ, Mueller JL. Direct EIT reconstructions of complex admittivities on a chest-shaped domain in 2-D. IEEE Trans Med Imaging. 2013 Apr;32(4):757-69. doi: 10.1109/TMI.2012.2237389. Epub 2013 Jan 9. |
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| ID | Term |
|---|---|
| D011030 | Pneumothorax |
| D010996 | Pleural Effusion |
| D011654 | Pulmonary Edema |
| D001261 | Pulmonary Atelectasis |
| D004646 | Emphysema |
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D010995 | Pleural Diseases |
| D012140 | Respiratory Tract Diseases |
| D008171 | Lung Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D012121 | Respiration, Artificial |
| D014057 | Tomography, X-Ray Computed |
| ID | Term |
|---|---|
| D058109 | Airway Management |
| D013812 | Therapeutics |
| D012151 | Resuscitation |
| D004638 | Emergency Treatment |
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| CT Scan | Device | Subjects will receive a CT scan as part of their standard of care, as specified in the enrollment criteria |
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012138 |
| Respiratory Therapy |
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D014054 | Tomography |