Presepsin (soluble CD14 subtype) is a novel marker with growing body of evidence supporting its accuracy and value for the diagnosis of sepsis. Patients with sepsis showed higher Prsepsin levels compared to those with SIRS. In addition the increase in Prsepsin levels correlates well with sepsis severity. Red cell distribution width variations are increased in a variety of medical conditions such as congestive heart failure, acute myocardial infarction, pulmonary embolism, pneumonia, critical illness, and cardiac arrest , and is a predictor of mortality in the general population. we aim to compare between Presepsin (soluble CD14) and RDW as prognostic markers in critically-ill patients with sepsis.

Inclusion Criteria:

• Male or female aged 18 65 years.
• Appropriate clinical data to enable classification into sepsis or SIRS according to Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
• Written informed consent by the patient or guardian

Exclusion Criteria:

• No informed consent
• Renal failure
• Liver failure
• Hematologic diseases
• Neutropenia
• Malignancy
• Chemotherapy during the previous 90 days.
• Patients using antibiotics at presentation

Patients admitted to the general ICU with sepsis or septic shock of both sexes between 18 and 65 years of age.